Amiodarone therapy and thyroid function


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Due to the widespread use of amiodarone in clinical practice, it is necessary to remember its possible undesirable effects. Treatment with amiodarone can lead to impaired thyroid functional activity from minor changes to hypothyroidism or severe thyrotoxicosis (amiodarone -induced thyreopathy-AIT). The questions of pathogenesis, diagnosis and treatment of AIT are discussed. Particular attention is paid to the examination of the patient before starting therapy with amiodarone. The question of canceling or continuing treatment with amiodarone in AIT should be addressed individually for each patient collaboratively by a cardiologist and endocrinologist.

Full Text

Restricted Access

About the authors

E. V Biryukova

FSBEI HE MSMSU n.a. A.I. Evdokimov of RMH

Email: lena@obsudim.ru
MD, Prof., Director of Teaching at the Department of . Endocrinology and Diabetology

N. M Platonova

FSBI “NMRC of Endocrinology" of RMH

References

  1. Singh B.N. Review Amiodarone as paradigm for developing new drugs for atrial fibrillation. J Cardiovasc. Pharmacol. 2008;52(4):300-5.
  2. Голицын С.П. Принципы фармакотерапии желудочковых нарушений ритма сердца. Клиническая фармакология и терапия. 1997;6(3):14-6.
  3. Vassallo P., Trohman R.G. Prescribing amiodarone: an evidence-based review of clinical indications. JAMA. 2007;298(11):1312-22.
  4. Singh N.B. Venkatesh N., Nademanee K., Josephson M.A., Kannan R. The historical development, cellular electrophysiology and pharmacology of amiodarone. Progress Cardiovascular Diseases. 1989;31(4):249-80.
  5. Naccarelli G.V., Rinkenberger R.L., Dougherty A.H., Giebel R.A. Amiodarone: pharmacology and antiarrhythmic and adverse effects. Pharmacotherapy. 1985;5(6):298-313.
  6. Bogazzi F., et al. Amiodarone and the thyroid: a 2012 update. J. Endocrinol. Invest. 2012;35(3):340-48.
  7. Мельниченко Г.А., Свириденко Н.Ю., Молашенко Н.В., и др. Индуцированная амиодароном дисфункция щитовидной железы (патогенез, диагностика, лечение). Тер. архив. 2003;75(8):92-6.
  8. Bongard V., Marc D., Philippe V., Jean-Louis M., Maryse L.M. Incidence rate of adverse drug reactions during long-term follow-up of patients newly treated with amiodarone. Am. J. Ther. 2006;13(4):315-19.
  9. Свириденко Н.Ю., Молашенко Н.В., Платонова Н.М., Атаманова Т.М., Сердюк С.Е., Бакалов С.А., Голицин С.П. Функциональное состояние щитовидной железы у пациентов, принимающих амиодарон. Методы коррекции тиреоидной дисфункции. Клиническая тиреоидология. 2004;2(4): 19-26.
  10. Cohen-Lehman J., Dahl P., Danzi S., Klein I. Effects of amiodarone therapy on thyroid function. Nat. Rev. Endocrinol. 2010;6(1): 34-41.
  11. van Beeren H.C., Bakker O., Wiersinga W.M. Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein. Mol. Cell. Endocrinol. 1995;112(1):15-9.
  12. Stoykov I., van Beeren H.C., Moorman A.F., et.al. Effect of amiodarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components. Eur. J. Endocrinol. 2007;56:695-702.
  13. Basaria S., Cooper D.S. Amiodarone and the thyroid. Am. J. Med. 2005;118(7):706-14.
  14. Narayana S.K., Woods D.R., Boos C.J. Management of Amiodarone-Related Thyroid Problems. Ther. Adv. Endocrinol. Metab. 2011;2(3):115-26.
  15. Narayana S.K., David R. Woods D.R., Christopher J. Boos. Management of Amiodarone- Related Thyroid Problems. Ther. Adv. Endocrinol. Metab. 2011;2(3):115-26.
  16. Yamato M., Wada K., Fujimoto M., et.al. Association between N-desethylamiodarone/ amiodarone ratio and amiodarone-induced thyroid dysfunction. Rur. J. Clin. Pharmacol. 2017;73(2):289-96.
  17. Martino E., Bartalena L., Bogazzi F.,Braverman L.E. The effects of amiodarone on the thyroid. Endocrine Reviews. 2001;22(2):240-54.
  18. Ahmed S., Van Gelder I.C., Wiesfeld A.C., Van Veldhuisen D.J., Links T.P Determinants and outcome of amiodarone-associated thyroid dysfunction. Clin. Endocrinol (Oxf). 2011;75(3):388-94.
  19. Mosher M.C. Amiodarone-induced hypothyroidism and other adverse effects. Dimens Crit. Care Nurs. 2011;30(2):87-93.
  20. Ursella S., Testa A., Mazzone M., Gentiloni Silveri N. Amiodarone-induced thyroid dysfunction in clinical practice. Eur. Rev. Med. Pharmacol. Sci. 2005;10:269-78.
  21. Poncin S., et al. Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. Endocrinology. 2008;149:424-33.
  22. Circu M.L., Aw T.Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radical Biology & Medicine. 2010; 48(6):749-62.
  23. Benjamens S., Dullaart R.P.F., Sluiter W.J., Rienstra M., van Gelder I. C., Links T. P. The clinical value of regular thyroid function tests during amiodarone treatment. Eur. J. Endocrinol. 2017;177(1):9-14.
  24. Barvalia U., Amlani B., Pathak R. Amiodarone-Induced Thyrotoxic Thyroiditis: A Diagnostic and Therapeutic Challenge. Case Rep. Med. 2014;2014:231651.
  25. Egloff M., Philippe J. Iodine excess induced thyroid dysfunction. Rev. Med. Suisse. 2016;12(515):804-9.
  26. Brooks M.J., Pattison D.A., Teo E. P., Price S., Gurvitch R. Amiodarone-induced destructive thyroiditis associated with coronary artery vasospasm and recurrent ventricular fibrillation. Eur. Thyroid J. 2013;2(1):65-67.
  27. Jabrocka-Hybel A., Bednarczuk T., Bartalena L., Pach D., Ruchata M., Grzegorz Kaminski G., Kostecka-Matyja M., Hubalewska-Dydejczyk A. Amiodarone and the thyroid. Endokrynologia Polska. 2015;66(2):176-96.
  28. Bogazzi F., Tomisti L., Di Bello V., Martino E. Amiodarone-induced thyrotoxicosis. G Ital Cardiol (Rome). 2017;18(3):219-29.
  29. Markou K., Georgopoulos N., Kyriazopoulou V., Vagenakis A.G. Iodine-Induced hypothyroidism. Thyroid. 2001;11(5):501-10.
  30. Kinoshita S., Hayashi T., Wada K., Yamato M., Kuwahara T.,Anzai T., Fujimoto M., Hosomi K., Takada M. Risk factors for amiodarone-induced thyroid dysfunction in Japan. J Arrhythm. 2016;32(6):474-80.
  31. Rozycka-Kosmalska M.,Michalak R, Kosmalski M., Wranicz J.K., Zieleniewski W., Cygankiewicz I. Clinical procedure in amiodarone-induced thyroid dysfunction. Pol, Merkur, Lekarski. 2016;40(235):46-52.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies