New possibilities of the treatment of breast cancer: microtubule inhibitors


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Abstract

Breast cancer (BC) is a biologically heterogeneous disease, and approximately 15-20% of the cases is accounted for by triple negative variant (ER/PR/HER2-negative), which is characterized by a relatively high frequency of progression and mortality. The place of eribulin mesylate in the treatment of this form of cancer is discussed. The target of eribulin action is tubulin. Currently, possibility of combination of eribulin with capecitabine is studied. It was concluded that the appearance of new drug with the original mechanism of action, eribulin mesylate, in the clinical oncology expands the possibilities of effective therapeutic effects not only in metastatic ER-negative and triple-negative forms of breast cancer resistant to standard therapeutic interventions, but also in the earlier stages of the disease.

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About the authors

V. F Semiglazov

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

G. A Dashyan

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

Email: dgarik@mail.ru
MD, Leading Researcher at the Department of Breast Tumors

P. V Krivorotko

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

R. M Paltuev

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

R. V Donskikh

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

T. Yu Semiglazova

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

K. Y Zernov

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

L. P Gigolaeva

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

V. S Apollonova

FSBI «SRI of Oncology n.a. N.N. Petrov» of RMH

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