Chemotherapy-associated polyneuropathy: problems and objects at the current stage of neurological assistance to oncological patients


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Abstract

Oncological diseases are the second most frequent cause of death both in the world and in Russia. Annually up to 14 million new cases of oncological diseases are registered in the world. The number of patients receiving chemotherapy increased significantly due to an increase in the survival period for breast cancer, colorectal cancer, bronchopulmonary cancer, bladder cancer, melanoma, leukemia, and non-Hodgkin’s lymphoma. Among patients receiving chemotherapeutic treatment, 30-40% will suffer from polyneuropathy of varying severity. Some patients will not be able to continue the main treatment due to the development of dose-limiting neurological complications. The problem of study of chemotherapy-induced polyneuropathy concerns all its aspects, including epidemiology, the phenomenology of standardization of approaches to prevention, effective treatment and specific approaches to rehabilitation, taking into account the main diagnosis. In the absence of neuroprotective therapy, particular attention should be paid to the timely diagnosis and adequate prevention of the development of polyneuropathy taking into account the individual patient characteristics. In the context of the accumulation of data on the safety of the use of certain physical and physiotherapeutic methods, the development of rehabilitation strategies, along with rational psychotherapy, is necessary to overcome the complications of life-saving treatment of the oncological process.

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About the authors

F. A Abbasov

FSBI “State Scientific Center of the Russian Federation “Federal Medical Biophysical Center n.a. A.I. Burnazyan FMBA of Russia"

M. A Anikina

FSBI “State Scientific Center of the Russian Federation “Federal Medical Biophysical Center n.a. A.I. Burnazyan FMBA of Russia"

O. S Zimnyakova

FSBI “State Scientific Center of the Russian Federation “Federal Medical Biophysical Center n.a. A.I. Burnazyan FMBA of Russia"

A. A Davtyan

FSBI “State Scientific Center of the Russian Federation “Federal Medical Biophysical Center n.a. A.I. Burnazyan FMBA of Russia"

E. V Bril

FSBI “State Scientific Center of the Russian Federation “Federal Medical Biophysical Center n.a. A.I. Burnazyan FMBA of Russia"

Email: e.brill@inbox.ru
PhD, Associate Professor at the Department of Neurology FSBEI FPE RMACPE of RMH, Chief Neurologist of FMBA of Russia, Head of Federal Neurological Center

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