Prognostic value of the dynamics of disseminated tumor cells in the bone marrow in patients with disseminated adenocarcinoma of the stomach or the esophagogastric junction


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Abstract

The article presents the results of the evaluation of disseminated tumor cells (DTCs) in the bone marrow (BM) of 32 patients with disseminated gastric cancer (GC) before and after the completion of first line chemotherapy (CT). Initially, DTCs were found (DTCs+) in 20 patients and were absent (DTCs-) in 12 patients. After the completion of CT, from 12 initial DTCs- cases, DTCs were still not detected in 8, but were found in 4 patients. From 20 initial DTCs+ cases, 13 patients continued to be diagnosed with DTCs in BM, and in 7 patients they were not detected. Comparative analysis has shown that persistence or appearance of DTCs in BM after CT is accompanied by a significant deterioration in both the progression-free survival and the overall survival of patients. Dynamics of DTCs in BM of patients against the background of CT is a prognostic marker for disseminated GC.

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About the authors

N. S Besova

FSBI “NMRC of Oncology n.a. N.N. Blokhin" of RMH

Email: besovans@mail.ru
PhD, Senior Researcher at the Department of Chemotherapy

E. S Obarevich

FSBI “NMRC of Oncology n.a. N.N. Blokhin" of RMH

O. A Beznos

FSBI “NMRC of Oncology n.a. N.N. Blokhin" of RMH

N. N Tupitsyn

FSBI “NMRC of Oncology n.a. N.N. Blokhin" of RMH

M. M Davydov

FSBI “NMRC of Oncology n.a. N.N. Blokhin" of RMH

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