Compression changes of vertebral bodies in patients with axial spon-diloarthritis, including ankilosing spondylitis


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Abstract

The evaluation of changes in the musculoskeletal system in patients with axial spondyloarthritis (axSpA) seems to be a relevant task. The article presents the results of study aimed to the determine the occurrence and features of deformations of the vertebral bodies in patients with AxSpA by assessment of spine X-rays and to compare the results with the frequency of decrease in bone mineral density (BMD) assessed by dual energy X-ray absorptiometry (DEXA). According to the results of the study, patients with axSpA showed a high occurrence of changes in the shape of vertebral bodies and a decrease in BMD. Each fifth patient with axSpA has changes in the shape of vertebral bodies with normal BMD. Thus, in order to form a full-fledged characterization of the state of the axial skeleton and adequate correction of the treatment of patients, combined use of the X-ray examination of the spinal column and DEXA is required.

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About the authors

I. Z Gaydukova

FSBEI HE North-Western State Medical University n.a. I.I. Mechnikov of RMH

Email: ubp1976@list.ru
MD, Associate Professor at the Department of Therapy and Rheumatology n.a. Eichwald

K. D Dorogoykina

FSBEI HE Saratov State Medical University n.a. V.I. Razumovsky of RMH

A. I Akulova

FSBEI HE Saratov State Medical University n.a. V.I. Razumovsky of RMH

M. A Mysin

FSBEI HE Saratov State Medical University n.a. V.I. Razumovsky of RMH

A. P Rebrov

FSBEI HE Saratov State Medical University n.a. V.I. Razumovsky of RMH

References

  1. Эрдес Ш.Ф., Бадокин В.В., Бочкова А.Г и др. О терминологии спондилоартритов. Научнопрактическая ревматол. 2015;53(6):657-60.
  2. Губарь Е.Е., Дубинина Т.В., Демина А.Б., Румянцева О.А., Шубин С.В., Годзенко А.А., Смирнов А.В., Глухова С.И., Урумова М.М., Эрдес Ш.Ф. Изменяется ли минеральная плотность кости при раннем аксиальном спондилоартрите? Научно-практическая ревматол. 2016;54(Прил. 1):29-32.
  3. Geusens P., Vosse D., van der Heijde D., Vanhoof J., van Tubergen A., Raus J., van der Linden S. High prevalence of thoracic vertebral deformities and discal wedging in ankylosing spondylitis patients with hyperkyphosis. J. Rheum. 2001;28(8): 1856-61.
  4. Sambrook P.N., Geusens P. The epidemiology of osteoporosis and fractures in ankylosing spondylitis. Ther. Adv. Musculoskelet. Dis. 2012;4(4):287-92.
  5. Vosse D., van der Heijde D., Landewe R., Geusens P., Mielants H., Dougados M., van der Linden S. Determinants of hyperkyphosis in patients with ankylosing spondylitis. Ann. Rheum. Dis. 2006;65(6):770-74.
  6. Tatort G., Rokita E., Korkosz M., Wröbel A. The ratio of anterior and posterior vertebral heights reinforces the utility of DXA in assessment of vertebrae strength. Calcif. Tissue Int. 2014;95(2):112-21.
  7. Tator G., Rokita E., Wröbel A., Korkosz M. Combining areal DXA bone mineral density and vertebrae postero-anterior width improves the prediction of vertebral strength. Skeletal. Radiol. 2013;42(12):1717-25.
  8. Arends S., Spoorenberg A., Bruyn G.A., Houtman P.M., Leijsma M.K., Kallenberg C.G., Brouwer E., van der Veer E. The relation between bone mineral density, bone turnover markers, and vitamin D status in ankylosing spondylitis patients with active disease: a cross-sectional analysis. Osteoporos. Int. 2011;22(5):1431-39.
  9. Korkosz M., Gqsowski J., Grzanka P., Gorczowski J., Pluskiewicz W., Jeka S., Grodzicki T Baseline new bone formation does not predict bone loss in ankylosing spondylitis as assessed by quantitative computed tomography (QCT): 10-year follow-up. BMC. Musculoskelet. Disord. 2011;31(12):121.
  10. Rudwaleit M., Landewe R., van der Heijde D., Listing J., Akkoc N., Brandt J., Braun J., Chou C.T., Collantes-Estevez E., Dougados M., Huang F., Gu J., Khan M.A., Kirazli Y., Maksymowych W.P., Mielants H., Serensen I.J., Ozgocmen S., Roussou E., Valle-Ohate R., Weber U., Wei J., Sieper J. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann. Rheum. Dis. 2009; 68(6):770-76.
  11. Гайдукова И.З., Ребров А.П. Программа для автоматического определения формы грудных и поясничных позвонков по результатам морфометрии рентгенограмм позвоночника, выполненных в боковой проекции. Свидетельство ФИПС о государственной регистрации программы ЭВМ № 2016661645 от 17.10.2016. http://www1. fips.ru/wps/portal/IPS_Ru#1502646150382.
  12. Лесняк О.В., Торопцова Н.В. Федеральные клинические рекомендации по диагностике и лечению остеопороза. М., 2014. http://rheumatolog. ru/experts/klinicheskie-rekomendacii.
  13. van der Linden S., Valkenburg H.A., Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum.1984; 27(4):361-68.
  14. Garrett S., Jenkinson T., Kennedy L.G., Whitelock H., Gaisford P., Calin A.A. New approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J. Rheum. 1994;21(12):2286-91.
  15. Lukas C., Landewe R.,Siepe rJ., Dougados M., Davis J., Braun J., van der Linden S., van der Heijde D. Assessment of SpondyloArthritis international Society. Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis. Ann. Rheum. Dis. 2009; 68(1):18-24.
  16. Calin A., Garrett S., Whitelock H., Kennedy L.G., O'Hea J., Mallorie P., Jenkinson T. A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J. Rheum. 1994; 21(12):2281-85.
  17. Jenkinson T.R., Mallorie P.A., Whitelock H.C., Kennedy L.G., Garrett S.L., Calin A. Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index. J. Rheum. 1994; 21(9):1694-98.
  18. Korkosz M., Gqsowski J., Leszczyrski P., Pawlak-Bus K., Jeka S., Kucharska E., Grodzicki T. High disease activity in ankylosing spondylitis is associated with increased serum sclerostin level and decreased wingless protein-3a signaling but is not linked with greater structural damage. BMC. Musculoskelet. Disord. 2013;19(14):99.
  19. Poddubnyy D., Fedorova A., Listing J., Haibel H., Baraliakos X., Braun J., Sieper J. Physical Function and Spinal Mobility Remain Stable Despite Radiographic Spinal Progression in Patients with Ankylosing Spondylitis Treated with TNF-a Inhibitors for Up to 10 Years. J. Rheum. 2016; 43(12):2142-48.
  20. Briot K., Durnez A., Paternotte S., Miceli-Richard C., Dougados M., Roux C. Bone oedema on MRI is highly associated with low bone mineral density in patients with early inflammatory back pain: results from the DESIR cohort. Ann. Rheum. Dis. 2013;72(12):1914-14.

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