Cardiovascular toxicity of fluoropirymidines


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Resumo

Cardiovascular toxicity of fluoropyrimidines is revealed in 1-19% of patients. Its frequency consistently increases with the administration of large single doses and long-term infusions, in case of combination with bevacizumab and platinum preparations; with concomitant coronary artery disease, in former smokers. Due to multiple pathophysiological mechanisms of damage to the heart and vessels, the manifestations of cardiovascular toxicity are diverse. The severity of the damage varies from asymptomatic changes in the electrocardiogram and arrhythmia to acute coronary syndrome and sudden death. The review describes the diagnostic algorithm and possible approaches to the treatment and prevention of repeated cardiovascular events associated with the use of fluoropyrimidines.

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Sobre autores

E. Kolomiets

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

Email: dr.kolomiets@mail.ru
cardiologisT., an advisory group of the Department of Hospital Therapy and Functional Diagnostics of the Department of Functional Diagnostics, Intensive Care and Rehabilitation

N. Besova

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

I. Kurmukov

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

Sh. Kashia

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

M. Narimanov

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

A. Sandomirskaya

FSBI NMRC of Oncology n.a. N.N. Blokhin of RMH

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