Prevention and treatment of late complications of Parkinson’s disease


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Abstract

The late stages of Parkinson’s disease are characterized by a change in the response to dopaminergic therapy with the formation of motor fluctuations and dyskinesias, the development of pronounced autonomic and cognitive insufficiency. The risk of development of motor fluctuations and dyskinesias after the initiation of therapy with levodopa is 10% per year. Therefore, in the late stages of Parkinson’s disease, it is necessary to modify the antiparkinsonian therapy with the crossover to prolonged dosage forms, and specific treatment of existent autonomic and cognitive disorders. Long-term therapy with amantadine is beneficial, because it reduces the likelihood and delays the development of dementia, helps to reduce the severity of motor fluctuations, and has an antidyskinetic effect.

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About the authors

V. V Zakharov

FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)

Email: zakharovenator@gmail.com
MD, Prof. at the Department of Nervous Diseases and Neurosurgery

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