RAMUCIRUMAB IN A COMBINATION WITH IRINOTECAN-BASED TWO-COMPONENT THERAPY REGIMEN AS THE SECOND LINE FOR THE TREATMENT OF DISSEMINATED GASTRIC CANCER. CASE REPORT


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详细

Background. Gastric cancer is one of the most widespread malignant tumors in the world, the treatment of which is receiving increasing attention every year. Description of the clinical case. The article presents a clinical case of successful use of ramucirumab in combination with FOLFIRI as the 2nd line of therapy for a patient with disseminated gastric adenocarcinoma.

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作者简介

T. Titova

N.N. Blokhin National Medical Research Center of Oncology

Moscow

N. Besova

N.N. Blokhin National Medical Research Center of Oncology

Email: besovans@mail.ru
PhD in Medical Sciences, Senior Researcher at the Department of Chemotherapy Moscow

V. Gorbunova

N.N. Blokhin National Medical Research Center of Oncology

Moscow

A. Fedenko

N.N. Blokhin National Medical Research Center of Oncology

Moscow

O. Malikhova

N.N. Blokhin National Medical Research Center of Oncology

Moscow

参考

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  3. Fuchs C.S., Tomasek J., Yong C.J., Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2014;383:31-39. PMID: 24094768. doi: 10.1016/S0140-6736(13) 61719-5].
  4. Wilke H., Muro K., Van Cutsem E., et al.; RAINBOW Study Group. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastrooesophageal junction adenocarcinoma (RAINBOW): a doubleblind, randomised phase 3 trial. Lancet Oncol. 2014;15:1224-35. PMID: 25240821. doi: 10.1016/S1470-2045(14) 70420-6]
  5. Yang L., Jiang X., Yan H., et al. Irinotecan-containing doublet treatment versus irinotecan monotherapy as second-line choice for advanced gastric cancer. BMC Gastroenterol. 2018;18:43. PMID: 29609559. doi: 10.1186/s12876-018-0772-4.
  6. Tabernero J., Yoshino T., Cohn A.L., et al. RAISE Study Investigators. Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study. Lancet Oncol. 2015;16(5):499-508. PMID: 25877855. doi: 10.1016/S1470-2045(15)70127-0.

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