METHODS OF RADIATION THERAPY OF LICHEN RUBER PLANUS


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Abstract

Lichen ruber planus (LRP) is an inflammatory dermatosis, often involving the mucous membranes of the oral cavity, esophagus, pharynx, conjunctiva, and also the dermal appendages. Depending on the nature of the lesions, there are typical and atypical forms of LRP of the skin and mucous membranes; and atypical forms are characterized by a more severe course, frequent relapses, torpidity of the treatment and the risk of malignant transformation. The etiology of LRP is not clear, but its development is associated with autoimmune destruction of basal keratinocytes by T cells. Treatment of LRP is not effective enough and is carried out primarily by applications of corticosteroids. In advanced and resistant processes, systemic corticosteroids, retinoids, immunosuppressants and biological agents are prescribed, the use of which is accompanied by a high incidence of side effects and complications, but does not prevent the recurrence of the disease. This review is devoted to modern methods of radiation therapy, used in the complex treatment of LRP of the skin and oral cavity, incl. photodynamic therapy, photochemical and extracorporeal photochemotherapy (photopheresis). A number of methods considered in the review (including photodynamic and extracorporeal photochemotherapy) are very promising and their use can significantly improve the effectiveness of therapy of LRP of the the skin and oral cavity, especially persistent and resistant to drug therapy.

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About the authors

Yu. V Molochkova

MRSRCI n.a. M.F. Vladimirsky

PhD, Senior Researcher, Department of Dermatovenereology and Dermatooncology

Yu. S Romanko

Medical Radiological Research Center n.a. A.F. Tsyb - Branch of FSBI “National Medical Research Radiological Center"

Yu. N Perlamutrov

A.E. Yevdokimov MSUMD

Department of Skin and Venereal Diseases

A. B Sekirin

MRSRCI n.a. M.F. Vladimirsky

Department of Physiotherapy and Rehabilitation

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