The features of the skin syndrome in infectious mononucleosis with high replicative activity of HHV-6 type in a child with drug allergy: a case report


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Abstract

According to modern concepts, infectious mononucleosis (IM) is a polyetiological disease. Currently, it is proven that along with the Epstein-Barr virus (EBV) other viruses of the Herpesviridae family are etiologically significant causative agents of mononucleosis, and IM may be caused by one of the viruses or their combinations in various phases of the infectious process. Exanthema against the background of HHV-6 infection is associated with the development of nonspecific vasculitis, caused by the damaging effect of immune factors on the vessel wall and the endotheliotropic nature of the virus, which can manifest as a macular, maculopapular or hemorrhagic rash. In the presented clinical case, the level of viral load and the influence of risk factors for toxicodermia, but not immunological disorders, correlate with the severity and nature of skin manifestations.

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About the authors

O. I Demina

Russian Medical Academy of Continuous Professional Education

L. N Mazankova

Russian Medical Academy of Continuous Professional Education

Tatiana A. Chebotareva

Russian Medical Academy of Continuous Professional Education

Email: t_sheina@mail.ru
MD, Associate Professor, Prof. at the Department of Children’s Infectious Diseases

S. A Kuznetsova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology; Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences

O. S Fedyanina

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology; Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences

D. S Tikhomirov

National Medical Research Center of Hematology

I. M Khegay

Pirogov Russian National Research Medical University

T. A Tupoleva

National Medical Research Center of Hematology

A. V Tebenkov

G.N. Speransky Children's City Clinical Hospital №9 of the Moscow Healthcare Department

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