Effect of micronutrient deficiency and dietary habits on the immune response and intestinal microbiocenosis in patients with inflammatory bowel diseases: a review


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Abstract

Currently, it is assumed that inflammatory bowel diseases (IBDs) occur when certain environmental factors influence the intestinal microflora in genetically predisposed individuals. In the pathogenesis of IBDs, different mechanisms such as damage to the epithelial barrier of the colon mucosa, changes in metabolism and virulent properties of commensal bacteria, the ratio of normal and pathogenic intestinal bacteria, dysregulation of immunological reactions, as well as genetic factors, play a role. The modern dynamics of life inevitably leads to a violation of the diet, which, according to many researchers, causes a change in the intestinal microflora. The review presents literature data on the effect of food components on the intestinal microflora, discusses the symptoms of micronutrient deficiency in patients with IBDs, and lists recommendations that can eliminate micronutrient deficiency.

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About the authors

Galiya R. Bikbavova

Omsk State Medical University

Email: galiya1976@mail.ru
PhD, Associate Professor at the Department of Hospital Therapy and Endocrinology

M. A Livzan

Omsk State Medical University

O. E Lopatina

Omsk State Medical University

References

  1. Kaplan G.G. The global burden of IBD: From 2015 to 2025. Nat Rev. Gastroenterol Hepatol. 2015;12:720-27. Doi: 10.1038/ nrgastro.2015.150.
  2. Ng S.C. Epidemiology of inflammatory bowel disease: focus on Asia. Best Pract Res Clin Gastroenterol. 2014;28:363-72. Doi: 10.1016/j. bpg.2014.04.003.
  3. Statovci D., Aguilera M., MacSharry J., Melgar S. The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Front Immunol. 2017;8:838. doi: 10.3389/fimmu.2017.00838.
  4. Yao C.K., Muir J.G., Gibson P.R. Review article: insights into colonic protein fermentation, its modulation and potential health implications. Aliment Pharmacol Ther. 2016;43:181-96. doi: 10.1111/apt.13456.
  5. Cani P.D., Everard A. Talking microbes: when gut bacteria interact with diet and host organs. Mol Nutr Food Res. 2016;60:58-66. Doi: 10.1002/ mnfr. 201500406.
  6. Galvez J., Rodriguez-Cabezas M.E., Zarzuelo A. Effects of dietary fiber on inflammatory bowel disease. Mol Nutr Food Res. 2005;49:601-8.
  7. Clemente J.C., Ursell L.K., Parfrey L.W., Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148:1258-70. doi: 10.1016/j.cell.2012.01.035.
  8. Rehman A., Rausch P., Wang J., et al. Geographical patterns of the standing and active human gut microbiome in health and IBD. Gut. 2016;65:238-48. doi: 10.1136/gutjnl-2014-308341.
  9. Халиф И.Л., Лоранская И.Д. Воспалительные заболевания кишечника (неспецифический язвенный колит и болезнь Крона): клиника, диагностика и лечение. М., 2004. 88 с.
  10. Gevers D., Kugathasan S., Denson L.A., et al. The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe. 2014;15:382-92. doi: 10.1016/j.chom.2014.02.005.
  11. Michail S., Durbin M., Turner D., et al. Alterations in the gut microbiome of children with severe ulcerative colitis. Inflamm Bowel Dis. 2012;18:1799-808. doi: 10.1002/ibd.22860.
  12. De Filippo C., Cavalieri D., Di Paola M., et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA. 2010;107:14691-696. doi: 10.1073/pnas.1005963107.
  13. Bonaz B.L., Bernstein Ch.N. Brain-Gut Interactions in Inflammatory Bowel Disease. Gastroenterology. 2013;144:36-49. Doi: 10.1053/j. gastro.2012.10.003.
  14. Takeshita K., Mizuno S., Mikami Y., et al. A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients. Inflamm Bowel Dis. 2016;22:2802-10.
  15. Kallinowski F., Wassmer A., Hofmann M.A., et al. Prevalence of enteropathogenic bacteria in surgically treated chronic inflammatory bowel disease. Hepatogastroenterology. 1998;45: 1552-58.
  16. Pilarczyk-Zurek М., Chmielarczyk А. Possible role of Escherichia coli in propagation and perpetuation of chronic inflammation in ulcerative colitis. BMC Gastroenterology. 2013;13:61. doi: 10.1186/1471-230X-13-61.
  17. Schultsz C., Moussa M., van Ketel R., et al. Frequency of pathogenic and enteroadherent Escherichia coli in patients with inflammatory bowel disease and controls. J. Clin Pathol. 1997;50:573- 79.
  18. Rhodes J.M. The role of Escherichia coli in inflammatory bowel disease. Gut. 2007;56(5):610-12.
  19. Ruseler-van Embden J.G., van der Helm R., van Lieshout L.M. Degradation of intestinal glycoproteins by Bacteroides vulgatus. FEMS Microbiol Lett. 1989;49(1):37-41.
  20. Профилактическая медицина как научнопрактическая основа сохранения и укрепления здоровья населения / Под ред. М.А. Поздняковой. Сборник научных трудов. Выпуск 4. Н. Новгород, 2017. C. 33-9
  21. Graham T.O., Kandil H.M. Nutritional factors in inflammatory bowel disease. Gastroenterol Clin N. Am. 2002;31:203-18.
  22. Han P.D., Burke A., Baldassano N., et al. Nutrition and inflammatory bowel disease. Gastroenerol Clin N. Am 1999;28:423-43.
  23. Lashner B.A., Provencher K.S., Seidner D.L., et al. The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis. Gastroenterology. 1997;112:29-32.
  24. Потрохова Е.А., Соботюк Н.В., Бочанцев С.В. Витамин D. и аутоиммунные заболевания. Российский вестник перинатологии и педиатрии. 2017;62(1):26-32.
  25. Бельмер С.В., Гасилина Т.В. Микроэлементы и микроэлементозы и их значение в детском возрасте. Вопросы современной педиатрии. 2008;7(6):91-6.
  26. Jeejeebhoy K.N. Clinical nutrition: 6. Management of nutritional problems of patients with Crohn's disease. CMAJ. 2002;166:913-18.
  27. Naber T.H.J., Van Den Hamer C.J.A., Baadenhuysen H.,Jansen J.B. The value of methods to determine zinc deficiency in patients with Crohn's disease. Scan J. Gastroenterol. 1998;33:514-23.
  28. Stein J., Hartmann F., Dignas A. Diagnosis and management of iron deficiency anemia in patients with IBD. Nat Rev Gastroenterol Hepatol. 2010;7(11):599-610. Doi: 10.1038/ nrgastro.2010.
  29. Dignass A.U., Gasche C., Bettenworth D., et al. European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases. J. Crohn's Colitis. 2014;9:211-22. doi: 10.1093/ecco-jcc/jju009.
  30. Тутельян В.А., Княжев В.А., Хотимченко С.А. и др. Селен в организме человека. Метаболизм. Антиоксидантные свойства. Роль в канцерогенезе. М., 2002. 201 с.
  31. Burr N.E., Hull M.A., Subramanian V. Folic Acid Supple- mentation May Reduce Colorectal Cancer Risk in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. J. Clin Gastroenterol. 2017;51(3):247-53. doi: 10.1097/MCG.0000000000000498.
  32. Голубкина Н.А., Синдирева А.В., Зайцев В.Ф. Внутрирегиональная вариабельность селенового статуса населения. Юг России: экология, развитие. 2017;12(1):107-27.
  33. Голубкина Н.А., Синдирева А.В., Зайко О.А., Алфтан Г. Селеновый статус Омской области. Сибирский экологический журнал. 2012;3:389-96.
  34. Weisshof R., Chermesh I. Micronutrient deficiencies in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2015;18:576-81. Doi: 10.1097/ MCO.0000000000000226.
  35. Seong-Eun K. Micronutrients Should Be Monitored in the Real Practice for Korean Inflammatory Bowel Disease Patients. Gut Liver. 2017;11(3):317-18. doi: 10.5009/gnl17135.
  36. Hwang C., Ross V., Mahadevan U. Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Inflamm Bowel Dis. 2012;18:1961-81. doi: 10.1002/ibd.22906.
  37. Barrett C.W., Singh K., Motley A.K., et al. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS One. 2013;8:e67845. doi: 10.1371/journal.pone.0067845.
  38. Del Pinto R., Pietropaoli D., Chandar A.K., et al. Association between inflammatory bowel disease and vitamin D. deficiency: a systematic review and meta-analysis. Inflamm Bowel Dis. 2015;21:2708-17. Doi: 10.1097/ MIB.0000000000000546.
  39. Alkhouri R.H., Hashmi H., Baker R.D., et al. Vitamin and mineral status in patients with inflammatory bowel disease. J. Pediatr Gastroenterol Nutr. 2013;56(1):89-92. Doi: 10.1097/ MPG.0b013e31826a105d.

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