Current approaches to the diagnostics and treatment of acromegaly
- Authors: Antsiferov M.B.1, Alekseeva T.M1, Andreeva A.V2
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Affiliations:
- Endocrinological Dispensary of the Moscow Healthcare Department
- V.V. Veresaev City Clinical Hospital, Moscow Healthcare Department
- Issue: Vol 26, No 4 (2019)
- Pages: 100-104
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/297981
- DOI: https://doi.org/10.18565/pharmateca.2019.4.100-104
- ID: 297981
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Abstract
Acromegaly is a severe chronic neuroendocrine disease that requires timely, adequate diagnosis and therapy. In the diagnosis of acromegaly, determination of the insulin-like growth factor-1 and growth hormone levels, as well as neuroimaging, play a key role. In the treatment of acromegaly, surgery is the best choice. In the absence of ability of surgical intervention or in the case of non-radicality of the surgical treatment, the pharmacotherapy is indicated. Somatostatin analogues (SSA) today are the most effective means of drug control of secretory and proliferative tumor activity. In the case of resistance to SSA, it is possible to transfer to another SSA, increase the dose of SSA, or add dopamine agonists and growth hormone receptor antagonists to the SSA.
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About the authors
Mikhail B. Antsiferov
Endocrinological Dispensary of the Moscow Healthcare Department
Email: antsiferov@rambler.ru
MD, Professor, Chief Moscow, Russia
T. M Alekseeva
Endocrinological Dispensary of the Moscow Healthcare DepartmentMoscow, Russia
A. V Andreeva
V.V. Veresaev City Clinical Hospital, Moscow Healthcare DepartmentMoscow, Russia
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