Depression in patients with polycystic ovary syndrome: a descriptive two-phase (prospective) study

Background. In the light of the transformation of scientific views on the problem of polycystic ovary syndrome (PCOS), the evaluation of the relationship between the mental and physical condition of patients, including in planning a pregnancy, take on great importance. Objective. Evaluation of the frequency and features of mood disorders in patients with PCOS seeking medical attention at the center of reproduction. Methods. The full-design descriptive two-phase study was conducted. Patients with PCOS (ESHRE/ASRM) seeking medical attention at the center of reproduction were examined by a psychiatrist, and 2 years later they were re-interviewed. The qualification of the condition was carried out on the basis of a clinical conversation in accordance with the ICD-10 criteria. Results. 116 patients of reproductive age were examined. Mental disorders were found in 76 (65.5%) women, 45 of them (38.8%) had mood disorders (affective disorders). 63 (54.3%) women took part in the second stage of study; 30 (47.6%) of them had a pregnancy ended in childbirth during the control period. Among 26 women diagnosed with the first stage of mood disorders, 18 (69.2%) had a relapse within two years. 15 women had a manifestation of depression in the same period. At least one episode of depression was detected in the same period in 15 patients who became pregnant for two years, 10 of them had depression in the postpartum period (33.3%, n=30). Conclusion. Patients with PCOS are highly susceptible to depression, characterized by a relapsing course and a tendency to increase in incidence over time. There is a high incidence of postpartum depression. All above mentioned demonstrates the need to develop approaches to the management of women with PCOS by multidisciplinary teams.

PCOS, depression, reproduction, multidisciplinary approach