The use of ramukirumab in the treatment of metastatic gastric cancer in real clinical practice


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Abstract

Background. Ramucirumab is the first anti-angiogenic targeted drug that improves survival as monotherapy or in combination with paclitaxel in a difficult population of patients with gastric cancer and of esophagogastric junction cancer after progression against the background of first-line therapy. Objective. Comparison of randomized clinical trial data and results obtained from real clinical practice. Methods. In the settings of the St. Petersburg City Clinical Oncology Dispensary, 24 cases of disseminated gastric cancer progressing on first-line therapy were prospectively analyzed. As a second-line treatment, ramutsirumab+paclitaxel regimen was administered. Results. During study, the following results were obtained: the duration of treatment with ramucruumab ranged from 2 to 16 months; median duration of treatment was 5 months, median overall survival - 18 months. Conclusion. The data obtained are comparable with the results of the randomized international registration RAINBOW study, which makes acceptable the use of this drug in real clinical practice.

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About the authors

Nataliya P. Belyak

City Clinical Oncology Dispensary; St. Petersburg State University

Email: dmpb@mail.ru
PhD, Oncologist, Chemotherapy Department (№ 11), City Clinical Oncology Dispensary; Teaching Assistant at the Department of Oncology 56, Veteranov Avenue, St. Petersburg 198255, Russian Federation

S. I Kutukova

City Clinical Oncology Dispensary; Pavlov First St. Petersburg State Medical University

St. Petersburg, Russia

R. V Orlova

City Clinical Oncology Dispensary; St. Petersburg State University

St. Petersburg, Russia

N. V Zhukova

City Clinical Oncology Dispensary; St. Petersburg State University

St. Petersburg, Russia

S. P Erdniev

City Clinical Oncology Dispensary

St. Petersburg, Russia

E. Yu Zorina

City Clinical Oncology Dispensary

St. Petersburg, Russia

I. V Avramenko

City Clinical Oncology Dispensary

St. Petersburg, Russia

N. Yu Antimonik

City Clinical Oncology Dispensary

St. Petersburg, Russia

N. V Popova

City Clinical Oncology Dispensary

St. Petersburg, Russia

A. K Ivanova

City Clinical Oncology Dispensary

St. Petersburg, Russia

A. V Androsova

City Clinical Oncology Dispensary

St. Petersburg, Russia

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