CXCR4 chemokine receptor expression in tumor tissue as an additional predictor factor for patients with colon cancer


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Abstract

Background. The incidence of colon cancer (CC) is increasing annually. Despite radical treatment methods, patients with favorable prognostic factors (early stage, high tumor differentiation) may have distant metastases after 12 months, and, on the contrary, patients with unfavorable prognostic factors (elevated cancer embryonic antigen level after surgical treatment, deep invasion -T4) may be in remission for a long time. Most likely, this is attributable to the processes of metastasis of tumor cells, which are currently not well studied. In particular, the participation of cytokines (chemokines) and their receptors in the process of metastasis is of scientific interest. Objective. Evaluation of the effect of CXCR4 chemokine receptor expression in tumor tissue on the relapse-free survival rate in patients with stage II (рT4N0M0) and stage III (pT4N1-2M0) colon cancer. Methods. The study included 113 patients: 53 with stage II CC (group A) and 60 with stage III CC (group B). Median patient follow-up period was 60 months. From the moment of follow-up, some patients were diagnosed with distant metastases at various times; in this connection, all patients in groups A and B were divided into subgroups. In patients of subgroup 1 of each group, no occurrence of distant metastases was recorded for 60 months using standard observational techniques; in patients of subgroup 2, the progression of the process in the form of the appearance of distant metastases was recorded. Further, the histological blocks of all patients were examined for the CXCR4 chemokine receptor expression by an immunohistochemical method. Results. The median disease-free period was significantly lower in the subgroups of patients with distant metastases, with high chemokine receptor expression in tumor tissue. Conclusion. Determination of CXCR4 chemokine receptor expression in tumor tissue can be used as an additional prognostic factor in the planning of adjuvant chemotherapy for CC patients.

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About the authors

R. V Orlova

St. Petersburg State University; City Clinical Oncology Dispensary; Clinical Hospital № 122

St. Petersburg, Russia

A. K Ivanova

City Clinical Oncology Dispensary

Email: oncolog.ivanova@yandex.ru
Oncologist, Department of Chemotherapy 56, Veteranov Avenue, St. Petersburg 198255, Russian Federation

G. A Raskin

Russian Research Center for Radiology and Surgical Technologies n.a. Acad. A.M. Granov

St. Petersburg, Russia

S. I Kutukova

City Clinical Oncology Dispensary; Pavlov First St. Petersburg State Medical University

St. Petersburg, Russia

A. V Androsova

City Clinical Oncology Dispensary

St. Petersburg, Russia

S. P Erdniev

City Clinical Oncology Dispensary

St. Petersburg, Russia

N. V Zhukova

St. Petersburg State University; City Clinical Oncology Dispensary

St. Petersburg, Russia

N. P Belyak

St. Petersburg State University; City Clinical Oncology Dispensary

St. Petersburg, Russia

N. V Popova

City Clinical Oncology Dispensary

St. Petersburg, Russia

I. V Avramenko

City Clinical Oncology Dispensary

St. Petersburg, Russia

N. Yu Antimonik

City Clinical Oncology Dispensary

St. Petersburg, Russia

E. Yu Zorina

City Clinical Oncology Dispensary

St. Petersburg, Russia

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