Evaluation of RETmRNA expression in malignant tumors of the salivary glands


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Abstract

Background. Treatment of locally advanced, recurrent or metastatic forms of malignant tumors of the salivary gland is a difficult task for clinical oncologists. Tumors of the salivary glands are insensitive to radiation and drug therapy. Objective. Evaluation of the frequency of RET mRNA expression in malignant tumors of the salivary glands as a possible prognostic factor for the course of the disease. Methods. The source of mRNA was archived pathological morphological samples of tumor tissue. Evaluation of mRNA expression of the RET kinase domain was performed using real-time polymerase chain reaction. Results. RET expression was detected in 13 of 48 cases, which amounted to 27.08% of the examined tumors (in other words, in almost one third of the examined samples). The expression level ranged from 0 to 0.205. Conclusion. The results obtained suggest that the RET mRNA expression level can be used not only as a prognostic, but also a predictive factor of the effectiveness of the multi-kinase inhibitors in this cohort of patients (after conducting prospective randomized trials).

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About the authors

S. I Kutukova

City Clinical Oncology Dispensary; Pavlov First St. Petersburg State Medical University

Email: dr.s.kutukova@gmail.com
PhD, Oncologist, Chemotherapy Department (№ 11), City Clinical Oncology Dispensary; Associate Professor, Department of Suigical Dentistry and Maxillofacial Surgery 56, Veteranov Avenue, St. Petersburg, 198255, Russian Federation

E. N Imyanitov

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

Yu. V Ivaskova

City Clinical Oncology Dispensary; Pavlov First St. Petersburg State Medical University

St. Petersburg, Russia

N. P Belyak

City Clinical Oncology Dispensary; St. Petersburg State University

St. Petersburg, Russia

A. Ya Razumova

Pavlov First St. Petersburg State Medical University

St. Petersburg, Russia

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