Migraine and endometriosis as comorbid diseases


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Abstract

Migraine and endometriosis have common clinical and epidemiological features that determine their comorbidity. The early age of menarche, the high prevalence among women of reproductive age, the frequent complaint of menorrhagia, as well as the high prevalence of concomitant functional disorders - all this is characteristic of migraine and endometriosis. For preparing a literature review, studies on the comorbidity of migraine and endometriosis from 1975 to 2019 in the international Pubmed database were analyzed. Analysis of the literature showed a high comorbidity of migraine and endometriosis. The relationship between the diseases is attributable to hormonal factors (prevalence in women of reproductive age with an early menarche in history, dependence on fluctuations in estrogen levels), common genes, central sensitization mechanisms, inflammatory mediators (nitrogen nitrate, prostaglandins and cytokines), which play an important role both in the pathogenesis of a migraine attack, and in development of foci of endometriosis. The article highlights the most controversial issues requiring further study, among which the choice of the most effective and safe hormonal drug for the treatment of endometriosis in patients with comorbid migraine is of the greatest practical importance.

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About the authors

U. A Bagirova

Sechenov First Moscow State Medical University (Sechenov University)

Elena G. Filatova

Sechenov First Moscow State Medical University (Sechenov University)

Email: eg-fHatova@mail.ru
MD, Professor at the Department of Nervous Diseases

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