The efficacy of photodynamic therapy in the correction of involutive skin changes

Background. In the search for new opportunities for skin rejuvenation, topical photodynamic therapy (PDT) with various light sources has all the theoretical prerequisites for use according to these indications. Methods. Depending on the PDT methodology and age, the patients were divided into groups. Group 1 (n=35) received PDT using a topical photosensitizer chlorin E6. 2 subgroups were distinguished in this group: 1A (n=17) - patients with age range of40-49 years, and 1B (n=18) -patients with age range of 50-60 years. The group 2 (n=35) received PDT with a topical photosensitizer chlorin E6 used in the electroporation method. Two subgroups were allocated in the group 2:2A (n=16) - patients with age range of40-49 years, and 2B (n=19) - patients with age range of 50-60 years. The efficacy of PDT with various methodological approaches was evaluated using cutometry. Results. In subgroup 1A, the Ua/Uf indicator increased by 20.6%, in subgroup 1B - by 18.1%. The most pronounced dynamics was noted in the group where PDT was performed with the photosensitizer electroporation. The cumulative cutometry index increased by 28.7% in the subgroup 2A, and by 26.1% in the subgroup 2B. After the course of therapy, the corneometry index increased by 29.3% in the subgroup 1A, and by 29.1% in the subgroup 1B. In the subgroup2A, the corneometry index increased by 35.3%, in the 2B subgroup - by 36.1%. In accordance with the gradation of this indicator, the corneometry index significantly increased and corresponded to the normal level (more than 59.9 relative units) after PDT in most patients of the subgroups 2A and 2B. Conclusion. PDT with chlorin electroporation promotes restoration of skin elasticity, as confirmed by the dynamics of the cumulative elasto-metry index (Ua/Uf), and increased skin moisture, as evidenced by the dynamics of the corneometry index.

involutive skin changes, photodynamic therapy, chlorin E, cutometry, corneometry