How to stop molluscum contagiosum by external remedies?


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Abstract

Molluscum contagiosum (MC) is a common viral skin infection that occurs in both adults and children, and is characterized by specific papular rashes. MC is prone to self-limitation and resolution, but there are a number of reasons that require its treatment: itching and eczematization around MC; numerous, long-existing and recurrent raches; rashes located on visible areas of the skin and forming a cosmetic defect that limits social activity. Most of the available treatment methods for MC, such as curettage, electrical and cryodestruc-tion, laser therapy, are traumatizing and cannot be used out of healthcare facility. In this regard, a 5% potassium hydroxide solution was successfully used for the treatment of MC, and it has demonstrated safety, efficacy and painlessness. Given its financial availability, it can be considered as the drug of choice for the treatment of MC at home, especially for children.

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About the authors

N. S Sirmays

Academy of Postgraduate Education, “Federal Scientific and Clinical Center" of the FMBA of Russia

Email: Natsirmais@mail.ru

E. V Vladimirova

Academy of Postgraduate Education, “Federal Scientific and Clinical Center" of the FMBA of Russia

Yu. A Markova

Academy of Postgraduate Education, “Federal Scientific and Clinical Center" of the FMBA of Russia

E. A Sanches

Academy of Postgraduate Education, “Federal Scientific and Clinical Center" of the FMBA of Russia

References

  1. Epstein W. L. Molluscum contagiosum. Semin Dermatol. 1992;11(3):184-89.
  2. Myskowsky P.L. Molluscum contagiosum. New insights, new directions. Arch Dermatol. 1997;133:1039-41.
  3. Laxmisha C, Thappa D.M., Jaisankar T.J. Clinical profile of molluscum contagiosum in children versus adults. Dermatol Online J. 2003;9(5):1.
  4. Dohil M.A., Lin P, Lee J., et al. The epidemiology of molluscum contagiosum in children. J Am Acad Dermatol. 2006;54(1):47-54. Doi: 10.1016/j. jaad.2005.08.035.
  5. Olsen J.R., Gallacher J., Piguet V., Francis N.A. Epidemiology of molluscum contagiosum in children: a systematic review. Fam Pract. 2014;31:130-36. doi: 10.1093/fampra/ cmt075.
  6. Solomon L.M., Telner P Eruptive molluscum contagiosum in atopic dermatitis. Can Med Assoc. J. 1966;95:978-79.
  7. Kakourou T., Zachariades A., Anastasiou T., et al. Molluscum contagiosum in Greek children: a case series. int J Dermatol. 2005;44:221-23. doi: 10.1111/j.1365-4632.2004.02074.x.
  8. Сирмайс Н.С., В.П. Ковалык Т. В. Рубашева. Контагиозный моллюск: современные представления и обзор методов лечения. Фарматека. 2018;спецвыпуск 5:18-23. Doi: 10.18565/ pharmateca.2018.s5.18-23.
  9. Gould D. An overview of molluscum contagiosum: a viral skin condition. Nurs Stand. 2008;22:45-8. doi: 10.7748/ns2008.06.22.41.45.c6577.
  10. Brown J., Janniger C.K., Schwartz R.A., Silverberg N.B. Childhood molluscum conta-giosum. int J Dermatol. 2006;45(2):93-9. doi: 10.1111/j.1365-4632.2006.02 737.x.
  11. National institute for Health and Care Excellence, 2012. Clinical knowledge summaries: Molluscum contagiosum (online). Available: http://cks.nice. org.uk/ molluscum-contagiosum (Accessed 17 September 2014).
  12. Roberts S. Warts and molluscum: an impractical guide. Arch Dis Child Educ Pract Ed. 2007;92: 199-200.
  13. Bunney M.H., Nolan M.W., Williams D.A. An assessment of methods of treating viral warts by comparative treatment trials based on a standard design. Br J Dermatol. 1976;94:667-79. doi: 10.1111/j.1365-2133.1976.tb05167.x.
  14. Phelps W.C., Alexander K.A. Antiviral therapy for human papillomaviruses: Rationale and prospects. Ann Intern Med. 1995;123:368-82.
  15. Bayerl C., Feller G., Goerdt S. Experience in treating molluscum contagiosum in children with imiquimod 5% cream. Br J Dermatol. 2003;149:25-9. doi: 10.1046/j.0366-077x.2003.05631.x.
  16. Schneider-Schaulies S., Dittmer U. Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression. J Gen Viro.l 2006;87:1423-38. doi: 10.1099/vir.0.81713-0.
  17. Wainberg M.A., Mills E.L. Mechanisms of virus-induced immune suppression. Can Med Assoc J. 1985;935:1321-67.
  18. Romiti R., Ribeiro A.P, Grinblat B.M., et al. Treatment of molluscum contagiosum with potassium hydroxide: a clinical approach in 35 children. Pediatr Dermatol. 1999;16:223-31. doi: 10.1046/j.1525-1470.1999.00066.x.
  19. Romiti R., Ribeiro A.P, Romiti N. Evaluation of the effectiveness of 5% potassium hydroxide for the treatment of molluscum contagiosum. Pediatr Dermatol. 2000;17:495. doi: 10.1046/j.1525-1470.2000.01837-7.x.
  20. Metkar A., Pande S., Khopkar U. An open, nonrandomized, comparative study of imiquimod 5% cream versus 10% potassium hydroxide solution in the treatment of molluscum contagiosum. ind J Dermatol Venereol Leprol. 2003;74(6):614-13.
  21. Seo S.H., Chin H.W., Jeong D.W., Sung H.W. An open, randomized, comparative clinical and histological study of imiquimod 5% cream versus 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Ann Dermatol. 2010;22(2):156-62. Doi: 10.5021/ ad.2010.22.2.156
  22. Handjani F, Behazin E., Sadati M.S. Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: An open randomized clinical trial. J Dermatolog Treat. 2014;25:249-50. doi: 10.3109/09546634.2013.832135.
  23. Short K.A., Fuller L.C., Higgins E.M. Double-blind, randomized, placebo-controlled trial of the use of topical 10% potassium hydroxide solution in the treatment of molluscum. Accepted Manuscript 18 contagiosum. Pediatr Dermatol. 2006; 23:279-81. doi: 10.1111/j.1525-1470.2006. 00235.x.
  24. Teixido C., Dfez O., Marsal J.R., et al. Efficacy and safety of topical application of 15% and 10% potassium hydroxide for the treatment of Molluscum contagiosum. Pediatr Dermatol. 2018;35:336-42. Doi: 10.1111/ pde.13438.

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