An algorithm for topical therapy of atopic dermatitis in children of the first year of life
- Authors: Murashkin N.N1,2,3, Savelova A.A2, Ivanov R.A1, Fedorov D.V1, Opryatin L.A1, Akhmad V.4
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Affiliations:
- National Scientific and Practical Center for Children's Health
- Central State Medical Academy
- Sechenov First Moscow State Medical University (Sechenov University)
- Kabardino-Balkarian State University
- Issue: Vol 26, No 8 (2019)
- Pages: 83-87
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312461
- DOI: https://doi.org/10.18565/pharmateca.2019.8.83-87
- ID: 312461
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Abstract
Background. Atopic dermatitis (AtD) is a multifactorial, most common inflammatory dermatosis. The structural features of the skin of children of the first year of life determine a number of clinical characteristics caused by dysfunction of the epidermal barrier with increased transepidermal water loss and pronounced hydrophobicity of the skin surface of children in this age period, which largely limits epidermal fluid absorption. Depending on the severity of the skin pathological process, a step-by-step algorithm for the topical therapy of AtD in children of the first year of life is proposed, including the differentiated use of topical glucocorticosteroids, wet wraps and topical calcineurin inhibitors - pimecrolimus in combination with emollients. Conclusion. According to modern recommendations for skin care for children of the first year of life, it is important to ensure regular hydration and skin cleansing. The most effective way to restore the protective function of the skin barrier is the use of agents aimed to restoring the stratum corneum and preventing excessive transepidermal water loss.
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About the authors
N. N Murashkin
National Scientific and Practical Center for Children's Health; Central State Medical Academy; Sechenov First Moscow State Medical University (Sechenov University)
Email: m_nn2001@mail.ru
A. A Savelova
Central State Medical Academy
R. A Ivanov
National Scientific and Practical Center for Children's Health
D. V Fedorov
National Scientific and Practical Center for Children's Health
L. A Opryatin
National Scientific and Practical Center for Children's Health
V. Akhmad
Kabardino-Balkarian State University
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