Modern etiological and clinical features of acute respiratory viral infection in children. Are there any prerequisites for antiviral therapy? Literature review


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

In recent years, the etiology of acute respiratory viral infections (ARVI) has expanded significantly due to the identification of new viruses, including viruses with pronounced immunosuppressive properties. When determining the treatment tactics for acute respiratory viral infections in children, it is important to consider the immaturity of their innate and adaptive immunity. The use of modern drugs with a broad antiviral and immunomodulatory effect can increase the effectiveness of antiviral protection, prevent the development of the disease or reduce the severity of its course. Given the high frequency of acute respiratory viral infections in children in the modern world, the development and implementation of antiviral agents that do not have cytotoxicity and have high clinical efficacy are required.

Full Text

Restricted Access

About the authors

I. N Zakharova

Russian Medical Academy of Continuous Professional Education

Email: zakharova-rmapo@yandex.ru
MD, Professor, Head of the Acad. G.N. Speransky Department of Pediatrics 28, Heroes Panfilovtsev Street, Moscow 125373, Russian Federation

I. M Osmanov

Bashlyaeva Children's City Clinical Hospital

Moscow, Russia

A. N Goryainova

Russian Medical Academy of Continuous Professional Education

Moscow, Russia

N. V Gavelya

Bashlyaeva Children's City Clinical Hospital

Moscow, Russia

E. V Ruchkina

Bashlyaeva Children's City Clinical Hospital

Moscow, Russia

References

  1. Arruda E., Ptkaranta A., Witek T.J., et al. Frequency and natural history of rhinovirus infections in adults during autumn. J Clin Microbiol. 1997;35(11): 2864-68.
  2. Barrett B, Hayney M., Muller D., et al. Medtation or Exercise for Preventing Acute Respiratory Infection: A Randomized Controlled Trial. Ann Fam Med. 2012;10:337-46.
  3. Bertino J.S. Cost burden of viral respiratory infections: issues for formulary decision makers. Am J Med. 2002;112(6, Suppl. 1):42-9. doi: 10.1016/s0002-9343(01)01063-4.
  4. Blomqvist S, Roivainen M., Puhakka T, et al. Virological and serological analysis of rhinovirus infections during the first two years of life in a cohort of children. J Med Virol. 2002;66(2):263-68. doi: 10.1002/jmv.2140.
  5. Broberg E, Niemea J., Lahti E., et al. Human rhinovirus C-associated severe pneumonia in a neonate. J Clin Virol. 2011;51(1):79-82. Doi: 10.1016/j. jcv.2011.01.018.
  6. Brownlee J.W, Turner R.B. New developments in the epidemiology and clinical spectrum of rhinovirus infections. Curr Opin Pediatr. 2008;20(1):67-71. doi: 10.1097/MOP.0b013e3282f41cb6.
  7. Fendrick A.M, Monto A.S., Nightengale B, Sarnes M. The economic burden of non-influenza-related viral respiratory tract infection in the Unted States. Arch Intern Med. 2003;163(4):487-94. Doi: 10.1001/ archinte.163.4.487.
  8. Fry A.M., Lu X., Olsen S.J., et al. Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. PLoS One. 2011;6(3):e17780. doi: 10.1371/journal. pone.0017780.
  9. Garcfa-Garcfa M.L., Calvo C., Pozo F, et al. Spectrum of respiratory viruses in children with community acquired pneumonia. Pediatr Infect Dis J. 2012;31(8):808-13. doi: 10.1097/INF0b013e3182568c67.
  10. Gern J. Rhinovirus and the intiation of asthma. Curr Opin Allergy Clin Immunol. 2009;9(1):73-8. doi: 10.1097/ACI.0b013e32831f8f1b.
  11. Ghazaly M., Nadel S. Characteristics of children admitted to intensive care with acute bronchiolitis. Eur J Pediatr. 2018;177(6):913-20. Doi: 10.1007/ s00431-018-3138-6.
  12. Ghosh S., Champlin R., Couch R., et al. Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients. Clin Infect Dis. 1999;29(3):528-32. doi: 10.1086/598627.
  13. Gutman J.A., Peck A.J., Kuypers J., Boeckh M. Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: a report of two cases. Bone Marrow Transplant. 2007;40(8):809-11. Doi: 10.1038/ sj.bmt.1705827.
  14. Gwattney J.M, Hendley J.O., Simon G., Jordan W.S. Rhinovirus infections in an industrial population. II. Characteristics of illness and antibody response. JAMA. 1967;202(6):494-500.
  15. Harris J.M., Gwaltney J.M. Incubation periods of experimental rhinovirus infection and illness. Clin Infect Dis. 1996;23(6):1287-90. Doi: 10.1093/ clinids/23.6.1287.
  16. Hicks L.A., Shepard C.W., Britz P.H., et al. Two outbreaks of severe respiratory disease in nursing homes associated with rhinovirus. J Am Geriatr Soc. 2006;54(2):284-89. doi: 10.1111/j.1532-5415.2005.00529.x.
  17. Imakita M, Shiraki K, Yutani C, Ishibashi-Ueda H. Pneumonia caused by rhinovirus. Clin Infect Dis. 2000;30(3):611-12. doi: 10.1086/313723.
  18. Iwane M.K, Prill M.M., Lu X., et al. Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J Infect Dis. 2011;204(11):1702-10. doi: 10.1093/infdis/ jir634.
  19. Jacobs S.E, Lamson D.M., George K.S., Walsh T.J. Human Rhinoviruses. Clin Microbiol Rev. 2013;26(1):135-62. doi: 10.1128/CMR. 00077-12.
  20. Johnsen M. Cough-Cold Report 2016. Drug Store News. February 2016. URL: http://www. drugstorenews.com/sites/drugstorenews.com/files. Cough-Cold_020816.pdf. Accessed June 8, 2016.
  21. Kotaniemi-Syrjanen A., Vainionpaa R., Reijonen T.M., et al. Rhinovirus-induced wheezing in infancy - the first sign of childhood asthma? J Allergy Clin Immunol. 2003;111(1):66-71. doi: 10.1067/mai.2003.33.
  22. Lessler J., Reich N.G., Brookmeyer R., et al. Incubation periods of acute respiratory viral infections: a systematic review. Lancet. Infect Dis. 2009;9(5):291-300. doi: 10.1016/S1473-3099(09)70069-6.
  23. Lieberman D., Shimoni A., Shemer-Avni Y, et al. Respiratory viruses in adults with communityacquired pneumonia. Chest. 2010;138(4):811-16. doi: 10.1378/chest.09-2717.
  24. Linder J.E., Kraft D.C., Mohamed Y., et al. Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades. J Allergy Clin Immunol. 2013;131(1):69-77. Doi: 10.1016/j. jaci.2012.09.033.
  25. Louie J.K., Roy-Burman A., Guardia-Labar L., et al. Rhinovirus associated with severe lower respiratory tract infections in children. Pediatr Infect Dis J. 2009;28(4):337-39. Doi: 10.1097/ INF.0b013e31818ffc1b.
  26. Louie J.K., Yagi S., Nelson F.A., et al. Rhinovirus outbreak in a long term care facility for elderly persons associated with unusually high mortality. Clin Infect Dis. 2005;41(2):262-65. doi: 10.1086/430915.
  27. Makela M.J., Puhakka T., Ruuskanen O., et al. Viruses and bacteria in the etiology of the common cold. J Clin Microbiol. 1998;36(2):539-42.
  28. Malesker M.A., Callahan-Lyon P., Ireland B., Irwin R.S. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report. Chest. 2017;152(5):1021-37. doi: 10.1016/j.chest.2017.08.009.
  29. Mermond S., Zurawski V, D'Ortenzio E., et al. Lower respiratory infections among hospitalized children in New Caledonia: a pilot study for the Pneumonia Etiology Research for Child Health Project. Clin Infect Dis. 2012;54(Suppl. 2):S180-89. doi: 10.1093/cid/ cir1070.
  30. Midulla F, Pierangeli A., Cangiano G., et al. Rhinovirus bronchiolitis and recurrent wheezing: 1-year followup. Eur Respir J. 2012;39(2):396-402. doi: 10.1183/09031936.00188210.
  31. Miller E.K., Bugna J., Libster R., et al. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatr. 2012;129(1):e60-7. doi: 10.1542/peds.2011-0583.
  32. Nokso-Koivisto J., Kinnari T.J., Lindahl P., et al. Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms. J Med Virol. 2002;66(3):417-20. Doi: 10.1002/ jmv.2161.
  33. Palmenberg A.C., Rathe J.A., Liggett S.B. Analysis of the complete genome sequences of human rhinovirus. J Allergy Clin Immunol. 2010;125(6):1190-201. doi: 10.1016/j.jaci.2010.04.010.
  34. Pappas D.E., Hendley J.O., Hayden F.G., Winther B. 2008. Symptom profile of common colds in school-aged children. Pediatr Infect Dis J. 2008;27(1):8-11. doi: 10.1097/INF.0b013e31814847d9.
  35. Pitkaranta A., Arruda E., Malmberg H., Hayden F.G. Detection of rhinovirus in sinus brushings of patients with acute community acquired sinusitis by reverse transcription-PCR. J Clin Microbiol. 1997;35(7): 1791-93.
  36. Rihkanen H., Ronkko E., Nieminen T., et al. Respiratory viruses in laryngeal croup of young children. J Pediatr. 2008;152(5):661-65. Doi: 10.1016/j. jpeds.2007.10.043.
  37. Pratter M.R. Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(Suppl. 1):72-4. Doi: 10.1378/ chest.129.1_suppl.72S.
  38. Rihkanen H., Carpen O., Roivainen M., et al. Rhinovirus in adenoid tissue. Int J Pediatr Otorhinolaryngol. 2004;68(7):903-8. doi: 10.1016/j.ijporl.2004.02.005.
  39. Ruohola A., Meurman O., Nikkari S., et al. Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria and viruses. Clin Infect Dis. 2006;43(11):1417-22. doi: 10.1086/509332.
  40. Sangil A., Calbo E., Robles A., et al. Aetiology of community-acquired pneumonia among adults in an H1N1 pandemic year: the role of respiratory viruses. Eur J Clin Microbiol Infect Dis. 2012;31(10):2765-72. doi: 10.1007/s10096-012-1626-6.
  41. Singleton R.J., Bulkow L.R., Miernyk K., et al. Viral respiratory infections in hospitalized and community control children in Alaska. J Med Virol. 2010;82(7):1282-90. doi: 10.1002/jmv.21790.
  42. Van Benten I., Koopman L., Niesters B., et al. Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants. Pediatr Allergy Immunol. 2003;14(5):363-70. doi: 10.1034/j.1399-3038.2003.00064.x.
  43. Winther B., Alper C.M., Mandel E.M., et al. Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season. Pediatr. 2007;119(6):1069-75. doi: 10.1542/peds.2006-3294.
  44. Wishaupt J., van der Ploeg T., de Groot R., et al. Single-and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen. BMC. Infect Dis. 2017;17:62. doi: 10.1186/s12879-016-2118-6.
  45. Xiang Z., Gonzalez R., Xie Z., et al. Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia. J Clin Virol. 2010;49(2):94-9. Doi: 10.1016/j. jcv.2010.07.013.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2020 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies