The role of vitamin D in preventing pregnancy complications in gestational diabetes mellitus


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Abstract

A brief review presents the results of studies conducted to identify a possible relationship between the vitamin D level in the body of a pregnant woman and the development of gestational diabetes mellitus. It seems possible and appropriate to use vitamin D to prevent the development and treatment of gestational diabetes mellitus, including its severe complications. Currently, however, there are no convincing data on the safety of prolonged use of drugs for mother and fetus, and threshold vitamin D levels for reasonable pharmacological correction have not been determined. The development of pharmacotherapeutic strategies requires carefully planned experimental and clinical studies.

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About the authors

Afag U. Kyazimova

Azerbaijan Medical University

Email: Lordman74@mail.ru
Cand. Sci. (Med.), Teaching Assistant at the Department of Pharmacology

R. M Abdullaeva

Azerbaijan Medical University

Department of Pharmacology

Sh. M Polukhova

Azerbaijan Medical University

Department of Pharmacology

S. M Babaeva

Azerbaijan Medical University

Department of Pharmacology

References

  1. Forouhi N, Wareham N. Epidemiology of diabetes. Medicine (Abingdon). 2014;42(12):698-702. doi: 10.1016/j.mpmed.2014.09.007.
  2. American Diabetes Association Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. Diabetes Care. 2018;41:S13-S27. doi: 10.2337/dc18-S002.
  3. International Diabetes Federation (IDF). Diabetes Atlas. 8th ed. IDF; Brussels, Belgium, 2017. URL: www.diabetesatlas.org/resources/2017-atlas.html
  4. Yang J., Cummings E.A., O'Connell C., Jangaard K. Fetal and neonatal outcomes of diabetic pregnancies. Obstet Gynecol. 2006;108;644-50. Doi: W.W97/01.AOG.0000231688.08263.47.
  5. Kamana K., Hua Z., Sumisti S. Gestational Diabetes Mellitus and Macrosomia: A Literature Review. Ann Nutr Metab. 2015;66(2):14-20. doi: 10.1159/000371628.
  6. Ross A. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press; Institute of Medicine (U.S.). Committee to Review; 2011. doi: 10.17226/13050 2011.
  7. Pike W, Christakos S. Biology and mechanisms of action of the vitamin D hormone. Endocrinol Metab Clin North Am. 2017;46(4):815-43. doi: 10.1016/j.ecl.2017.07.001.
  8. Aghaja fari F, Nagulesap illa i T., Ronksley P, et al. Association between serum maternal 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ. 2013;346:f1169. Doi: 10.1136/ bmj.f1169.
  9. Bourlon P, Billaudel B., Faure-Dussert A. Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol. 1999;160(1);87 95. doi: 10.1677/joe.0.1600087
  10. Zhou Q, Hou F, Guo Z., et al. 1,25-dihydroxyvitamin D improved the free fatty-acid-induced insulin resistance in cultured C2C12 cells. Diabet Metab Res Rev. 2008;24(6):459-64. Doi: 10.1002/ dmrr.873
  11. Johnson J., Grande J., Roche P, Kumar R. Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol. 1994;267(3 Pt 1):E356-60. Doi:10.1152/ ajpendo.1994.267.3.E356
  12. Ptttas A, Lau J., Hu F, et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92;2017-29. doi: 10.1210/jc.2007-0298
  13. Dunlop T, Vaisanen S., Frank C., et al. The human peroxisome proliferator-activated receptor 6 gene is a primary target of 1a, 25-dihydroxyvitamin D3 and its nuclear receptor. J Mol Biol. 2005;349(2):248 60. doi: 10.1016/j.jmb.2005.03.060
  14. Maestro B., Campion J., Davila N., et al. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocrine J 2000;47(4):383-91. Doi:10.1507/ endocrj.47.383.
  15. Maestro B., Molero S., Bajo S., et al. Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3. Cell Biochem Funct. 2002;20(3):227-32. Dov.10.1002/cbf.951.
  16. Karras S., Fakhoury H., Muscogiuri G., et al. Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications. Ther Adv Musculoskelet Dis. 2016;8(4):124-35. doi: 10.1177/1759720X16656810.
  17. Rizzo G., Garzon S., Fichera M. et al. Vitamin D and Gestational Diabetes Mellitus: Is There a Link? Antioxidants (Basel). 2019;8(11);pii:E511. doi: 10.3390/antiox8110511.
  18. Bennett S., McPeake J., McCance D.Maternal Vitamin D status in type 1 diabetic pregnancy: impact on neonatal vitamin d status and association with maternal glycaemic control. PLoS One. 2013;8(9);e74068. doi: 10.1371/journal. pone.0074068.
  19. Clifton-Bligh R., McElduff P, McElduff A. Maternal vitamin D deficiency, ethnicity and gestational diabetes. Diabet Med. 2008;25(6);678-84; doi: 10.1111/j.1464-5491.2008.02422.x.
  20. Soheilykhah S., Mojibian M., Rashidi M., et al. Maternal vitamin D status in gestational diabetes mellitus. Nutr Clin Pract. 2010;25;524-27. doi: 10.1177/0884533610379851.
  21. Hosseinnezhad A., Holick M. Vitamin D for Health: A Global Perspective. Mayo Clin Proc. 2013;88(7);720-55. Doi: 10.1016/j. rnayocp.o013.05.01l.
  22. Shin J., Choi M., Longtine M., et al. Vitamin D effects on pregnancy and the placenta. Placenta. 3010;31(13):1037-34. Doi: 10.1016/j. p|pcentp.2010.08.015.
  23. Lapillonne A. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Med Hypotheses. 2010;74(1):71-5. Doi: 10.1016/j. mehy.2009.07.054.
  24. El-Fakhri N., McDevitt H., Shaikh M., et al. Vitamin D and its effects on glucose homeostasis, cardiovascular function and immune function. Horm Res Paediatr. 3014;81(6):363-78. doi: 10.1159/000357731.
  25. Miliku K., Vinkhuyzen A., Blanken L. Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. J Clin Nutr. 2016;103(6):1514-22. Doi: 10.3945/ ajcn.115.123752.
  26. Mutlu N., Esra H., Begum A., et al. Relation of maternal vitamin D status with gestational diabetes mellitus and perinatal outcome. Afr Health Sci. 2015;15(2).-523-31. doi: 10.4314/phs.v15i2.27.
  27. Zhang Y., Gong Y., Xue H., et al. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG. 2018;125(7):784-93. doi: 10.1111/14710528.15060.
  28. Comittee on Obstetric Practice, ACOG Committee Opinion No. 495 Vitamin D Screening and supplementation during pregnancy. Obstet Gynecol. 2011;118:197-98. Doi: 10.1097/ AOG.0b013e318227f06b.
  29. Ross A., Manson J., Abrams S., et al. The 2011 report on Dietary Reference Intakes for calcium and vitamin D from the Institute of medicine: What clinicians need to know. J Clin Endocrinol. 2011;96(1):53-8. doi: 10.1210/jc.2010-2704.
  30. Jamilian M., Samimi M., Ebrahimi F, et al. The effects of vitamin D and omega-3 fatty acid co-supplementation on glycemic control and lipid concentrations in patients with gestational diabetes. J Clin Lipidol. 2017;11(2);459-68. Doi: 10.1016/j. 'pcI.2017.01.01132.
  31. Dwarkanath P, Ponnusamy V, Thomas T., et al. Relationship of early vitamin D concentrations and gestational diabetes mellitus in Indian pregnant women. Front Nutr. 2019;6:116. Doi.Org/10.3389/ Fnut.2019.00116.
  32. Rajput R., Vohra S., Nanda S., et al. Severe 25(OH) vitamin-D deficiency: a risk factor for development of gestational diabetes mellitus. Diabetes Metab Syndr. 2019;13(2)'.985-87. Doi: 10.1016/j. dsx.2019.01.004.
  33. Burris H., Camargo C.A. Jr. Vitamin D and gestational diabetes mellitus. Curr Diab Rep. 2014;14(1):451. doi: 10.1007/s11892-013-0451-3.
  34. Szymczak-Pajor I., Sliwinska A. Analysis of Association between Vitamin D Deficiency and Insulin Resistance. Nutrients. 2019;11(4):794. doi: 10.3390/nu11040794.

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