Genetic biomarkers of various ischemic stroke subtypes


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Background. Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. There are atherothrombotic (ATS) and cardioembolic (CES) subtypes of IS. For timely diagnosis and prediction of outcomes for different IS subtypes, an important task is to identify the most informative biomarkers, including genetic ones. Objective. Search for genetic biomarkers to predict the outcome of various IS subtypes based on an analysis of the CD46 gene expression level. Methods. The study used RNA samples of 79 unrelated individuals, including 21 patients with CES, 20 with ATS, 21 with transient ischemic attack, and 17 healthy individuals. In order to study the role of the CD46 gene in the development of IS, we performed a molecular genetic analysis of its expression level. Results. The important role of the CD46 gene in the development of ATS has been shown. A comparative analysis with the control group showed that ATS men showed a significant increase in the CD46 gene expression level, while in women, on the contrary, the the CD46 gene expression level was significantly lower. Conclusion. The data obtained indicate the important role of the CD46 gene in the development of this pathology and the possibility of its use as a genetic biomarker of the atherothrombotic IS.

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作者简介

Guzel Minibaeva

Bashkir State Medical University

Email: Guzel-hisamieva@rambler.ru
Postgraduate Student at the Department of Neurology IPGE Ufa, Russia

L. Novikova

Bashkir State Medical University

Ufa, Russia

T. Viktorova

Bashkir State Medical University

Ufa, Russia

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