Modern concepts of microbial biofilms


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Abstract

A review of current ideas about the microbial biofilms is presented. Stages of development, structure and components of biofilms as possible factors of antibiotic resistance are discussed. Examples of various types of antibiotic resistance in biofilm bacteria are provided. The process of collective regulation through coordination of gene expression in a bacterial population that mediates the specific behavior of cells is considered. Particular attention is paid to the role of microbial biofilms in the development of gynecological pathology. The authors evaluate various approaches that affect the components of biofilms in order to reduce their resistance/integrity using a combination of antibacterial drugs and enzymes of various origins. Methods of influence on matrix components, signaling molecules, and adhesion factors are recognized as promising. A model of the effect on biofilms using hyaluronidase is presented.

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Aleksey A. Khryanin

Novosibirsk State Medical University

Email: khryanin@mail.ru
Dr. Sci. (Med.), Professor at the Department of Dermatovenerology and Cosmetology

G. Yu Knorring

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

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