Pharmacoepidemiological analysis of the use of systemic antimicrobial agents for postpartum infectious complications in obstetric institutions
- Authors: Korobkov N.A.1, Dar’ina M.G2,3, Svetlichnaya Y.S2,3
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Affiliations:
- Military Medical Academy n.a. S.M. Kirov
- North-Western State Medical University n.a. I.I. Mechnikov
- Medical Information and Analytical Center
- Issue: Vol 27, No 6 (2020)
- Pages: 82-87
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312683
- DOI: https://doi.org/10.18565/pharmateca.2020.6.82-87
- ID: 312683
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Abstract
Background. When conducting rational etiotropic therapy of postpartum infection, observation of the rules for administering antibiotics and the presence of a drug formulary in the obstetric institution are of great importance. Objective. Analysis of the stereotypes of prescribing systemic antimicrobials for postpartum infectious complications in obstetric institutions of St. Petersburg. Methods. A retrospective multicenter pharmacoepidemiological study was conducted. Local protocols for starting empirical therapy of postpartum infectious and inflammatory complications of all obstetric institutions under the jurisdiction of the St. Petersburg Healthcare Committee were analyzed. Examination of childbirth histories of 150 patients after abdominal delivery with the development of endometritis in the postoperative period was performed. Results. Some of the combinations used in the obsteric institutions were irrational from the point of view of the pharmacodynamic profile of the antibiotic, and they did not have advantages over monotherapy with combined penicillins from the microbiological point of view. Also, the volume and quality of the etiological diagnosis were not high. Conclusion. The current practice of using antibiotics for postpartum infectious complications did not match the recommended guidelines for every fifth puerpera.
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About the authors
Nikolay A. Korobkov
Military Medical Academy n.a. S.M. Kirov
Email: nikolai_korobkov@mail.ru
Dr. Sci. (Med.), Associate Professor at the Department of Obstetrics and Gynecology
M. G Dar’ina
North-Western State Medical University n.a. I.I. Mechnikov; Medical Information and Analytical Center
Yu. S Svetlichnaya
North-Western State Medical University n.a. I.I. Mechnikov; Medical Information and Analytical Center
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