Abemacyclib - new options for the treatment of hormone-positive metastatic breast cancer with CDK4/6 inhibitors


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Аннотация

The review focuses on abemacyclib, a selective continuous CDK4/6 inhibitor with activity against CDK4 14 times higher than against CDK6. A group of patients with HR+HER2- metastatic breast cancer (BC) was identified, for which the appointment of abemacyclib is optimal. Abemacyclib is registered in combination with endocrinotherapy as the first line of treatment for HR+HER2-BC and after progression on hormone therapy. The use of abemacyclib as monotherapy in patients with HR+HER2-BC with poor prognosis who received intensive previous treatment showed encouraging efficacy and satisfactory tolerance.

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Авторлар туралы

T. Semiglazova

N.N. Petrov National Medical Research Center of Oncology; North-Western State Medical University n.a. I.I. Mechnikov

Email: tsemiglazova@mail.ru
Dr. Sci. (Med.), Associate Professor, Head of the Division - Leading Reseacher at the Scientific Department of Innovative Methods of Therapeutic Oncology and Rehabilitation, N.N. Petrov National Medical Research Center of Oncology; Professor at the Department of Oncology, North-Western State Medical University n.a. I.I. Mechnikov 68, Leningradskaya str., Pesochny settlement, St. Petersburg 197758, Russian Federation

O. Volynshchikova

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

V. Semiglazov

N.N. Petrov National Medical Research Center of Oncology; Pavlov University

St. Petersburg, Russia

V. Klimenko

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

N. Brish

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

Yu. Alekseeva

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

V. Klyuge

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

A. Krutov

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

R. Paltuev

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

B. Kasparov

N.N. Petrov National Medical Research Center of Oncology

St. Petersburg, Russia

P. Krivorotko

N.N. Petrov National Medical Research Center of Oncology; North-Western State Medical University n.a. I.I. Mechnikov

St. Petersburg, Russia

V. Semiglazov

N.N. Petrov National Medical Research Center of Oncology; North-Western State Medical University n.a. I.I. Mechnikov

St. Petersburg, Russia

Әдебиет тізімі

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