Changes in type 1 and 3 collagen in photodamaged skin after photodynamic therapy: review and experience
- Authors: Surkichin S.I1, Kogan E.A2, Kholupova L.S1
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Affiliations:
- Central State Medical Academy of Department for Presidential Affairs of the Russian Federation
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 27, No 8 (2020)
- Pages: 68-72
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312766
- DOI: https://doi.org/10.18565/pharmateca.2020.8.68-72
- ID: 312766
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Abstract
Background. Skin aging occurs in accordance with the general patterns of age-related involution (biological or chronological aging), as well as under the influence of environmental factors, the most important of which is ultraviolet radiation (photodamage and photoaging of the skin). Objective. Evaluation of the amount of type 1 and 3 collagen before and after a course of photodynamic therapy (PDT) sessions using a chlorin E6-based photosensitizer. Methods. Punch biopsy samples of the parotid region of 3 women 38-45 years old with stage II-III photoaging of the skin (before and after the course of PDT sessions using chlorin E6 once every 7 days No. 5) were examined. Immunohistochemical parameters (type 1 and 3 collagen) were determined. Results. In histological samples taken after exposure, a thin keratinizing epidermis was observed; angiogenesis increased in comparison with the «before» sample; there was an infiltrate of lymphohistiocytic elements. According to the immunohistochemical examination, the expression of type 1 collagen had a strong intensity (4 points), and the expression of type 3 collagen had a weak intensity (2 points). Conclusion. Thus, it can be concluded that the PDT effect in photoaging leads to the normalization of the types 1 and 3 collagen ratio. The application of chlorin E6 derivatives as a photosensitizer leads to changes similar to the use of 5-aminolevulinic acid for type 1 and 3 collagen and can be recommended for clinical use.
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About the authors
S. I Surkichin
Central State Medical Academy of Department for Presidential Affairs of the Russian FederationCand. Sci. (Med.), Associate Professor
E. A Kogan
Sechenov First Moscow State Medical University (Sechenov University)
L. S Kholupova
Central State Medical Academy of Department for Presidential Affairs of the Russian Federation
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