Resistin levels and metabolic parameters in patients type 2 diabetes mellitus in combination with hypothyroidism

Background. In the Russian Federation, as in the whole world, the number of patients with type 2 diabetes mellitus (DM2) continues to increase. Also, there is currently an increase in the number of patients with hypothyroidism. The prevalence of hypothyroidism among DM2 patients is higher than in the general population. A decrease in the function of the thyroid gland in persons with DM2 aggravates the already existing disorders of carbohydrate and lipid metabolism, and insulin resistance. Objective: to assess the relationship between the level of resistin and hormone-metabolic parameters in patients with hypothyroidism, DM2 and their combination. Methods. Three groups of women were examined: 42 women with primary hypothyroidism, 38 women with T2DM and 39 women with a combination of DM2 and primary hypothyroidism. All the subjects underwent an anthropometric examination, the parameters of carbohydrate and lipid metabolism, and the level of resistin were examined. The results of a survey of 35 apparently healthy women, divided into older and younger groups, were used as controls. Results. Women with DM2 and its combination with hypothyroidism were found to have hyperglycemia and hyperinsulinemia. An increase in total cholesterol, triglyceride levels, and coefficient of atherogenicity was found in all groups of the examined. Patients with hypothyroidism and patients with DM2 have elevated resistin levels. Conclusion. Women with DM2 and its combination with hypothyroidism showed insulin resistance, which was accompanied by compensatory hyperinsulinemia. A significant increase in the level of resistin was found in patients with hypothyroidism and patients with DM2. Atherogenic dyslipidemia was found in all patients. Resistin affects the development of insulin resistance in patients with DM2 and hypothyroidism.

resistin, insulin resistance, atherogenic dyslipidemia, type 2 diabetes, hypothyroidism