What should the practitioner remember when managing patients with diabetic neuropathy


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Abstract

The article reflects the problems of differential diagnosis of diabetic neuropathy. A description of the most common forms of diabetic complications associated with damage to the peripheral nervous system is presented, taking into account the modern classification of existing disorders. The article discusses the most common diseases and conditions with which a practitioner needs to make a differential diagnosis when examining patients with prediabetes or established diabetes mellitus, including compression-ischemic neuropathies associated with damage to the nerves of the upper and lower extremities, deficiency states, in particular B 12-deficiency anemia, which often develops in patients taking antidiabetic drugs such as metformin for a long time. Their main clinical manifestations are described; the examination methods necessary for the diagnosis are given.

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About the authors

Elena V. Isakova

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Email: isakovael@mail.ru
Dr. Sci. (Med.), Leading Researcher at the Neurological Department Moscow, Russia

S. V Kotov

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Moscow, Russia

References

  1. Feldman E.L., Callaghan B.C. Pop-Busui R., et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1):42. doi: 10.1038/s41572- 019-0097-9.
  2. Дедов И.И., Шестакова М.В., Викулова О.К. Эпидемиология сахарного диабета в Российской Федерации: клинико-статистический анализ по данным Федерального регистра сахарного диабета. Сахарный диабет. 2017;20(1):13-41.
  3. Williams S.M., Eleftheriadou A., Alam U., et al. Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review. Diabet Ther. 2019;10(6):1995-2021. doi: 10.1007/s13300-019-00693-0.
  4. Brown S.J., Handsaker J.C., Bowling F.L., et al. Diabetic peripheral neuropathy compromises balance during daily activities. Diabet Care. 2015;38(6):1116-22. Doi: 10.2337/ dc14-1982.
  5. Allet L., Armand S., de Bie R.A., et al. Clinical factors associated with gait alterations in diabetic et al. patients. Diabet Med. 2009;26(10):1003-9. doi: 10.1111/j.1464-5491.2009.02811.x.
  6. Hewston P., Deshpande N. Falls and Balance Impairments in Older Adults with Type 2 Diabetes: Thinking Beyond Diabetic Peripheral Neuropathy.Can J Diabetes. 2016;40(1):6-9. Doi: 10.1016/j. jcjd.2015.08.005.
  7. Sasaki H., Kawamura N., Dyck P.J., et al. Spectrum of diabetic neuropathies. Diabet Int. 2020;11(2):87-96. doi: 10.1007/s13340-019-00424-7.
  8. Котов С.В., Рудакова И.Г., Исакова Е.В. и др. Диабетическая асимметричная проксимальная нейропатия Журнал неврологии и психиатрии им. C.C. Корсакова. 2017;117(1):59- 62.
  9. Котов С.В., Исакова Е.В., Лиждвой В.Ю. и др. Эффективность препарата кокарнит при диабетической нейропатии. Журнал неврологии и пси -хиатрии им. C.C. Корсакова. 2018;118(1):3742
  10. Oh J. Clinical spectrum and diagnosis of diabetic neuropathies. Korean J Intern Med. 2020;35(5):1059-69. Doi: 10.3904/ kjim.2020.202.
  11. Hicks C.W, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019;19(10):86. doi: 10.1007/s11892-019-1212-8.
  12. Feldman E.L., Callaghan B.C., Pop-Busui R., et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1):42. doi: 10.1038/s41572-019- 0097-9.
  13. Pop-Busui R., Boulton A.J., Feldman E.L., et al. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diab Care. 2017;40(1):136-54. doi: 10.2337/dc16-2042.
  14. Rydberg M., Zimmerman M., Gottsäter A., et al. Diabetes mellitus as a risk factor for compression neuropathy: a longitudinal cohort study from southern Sweden. BMJ. Open Diab. Res. Care. 2020;8(1):e001298. Doi: 10.1136/ bmjdrc-2020-001298.
  15. Rota E., Morelli N. Entrapment neuropathies in diabetes mellitus. World J Diab. 2016;7(17):342-doi: 10.4239/wjd.v7.i17.342.
  16. Baskerville R., McCartney D.E., McCartney S.M., et al. Tendinopathy in type 2 diabetes: a condition between specialties? Br J Gen Pract. 2018;68(677):593-94. Doi: 10.3399/ bjgp18X700169.
  17. Urits I., Gress K., Charipova K., et al. Recent Advances in the Understanding and Management of Carpal Tunnel Syndrome: a Comprehensive Review. Curr Pain Headache Rep. 2019;23(10):70. doi: 10.1007/s11916-019-0811-z.
  18. Wright A.R., Atkinson R.E. Carpal Tunnel Syndrome: An Update for the Primary Care Physician. Hawaii J. Health Soc. Welf. 2019;78(11 Suppl. 2):6-10. PMID: 31773104; PMCID: PMC6874691.
  19. Multanen J., Ylinen J., Karjalainen T, et al. Structural validity of the Boston Carpal Tunnel Questionnaire and its short version, the 6-Item CTS symptoms scale: a Rasch analysis one year after surgery. BMC. Musculoskelet Disord. 2020;21(1):609. doi: 10.1186/s12891-020-03626-2.
  20. Wade R.G., Griffiths T.T., Flather R., et al. Safety and Outcomes of Different Surgical Techniques for Cubital Tunnel Decompression: A Systematic Review and Network Meta-analysis. JAMA. Netw Open. 2020;3(11):e2024352. Doi: 10.1001/ jamanetworkopen.2020.24352.
  21. Gougoulias N., Lampridis V., Sakellariou A. Morton's interdigital neuroma: instructional review. EFORT Open Rev. 2019 23;4(1):14-24. doi: 10.1302/2058-5241.4.180025.
  22. de Jager J., Kooy A., Lehert P., et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010;340:c2181. Doi: 10.1136/ bmj.c2181.
  23. Aroda V.R., Edelstein S.L., Goldberg, et al. Diabetes Prevention Program Research Group. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metabol. 2016;101(4):1754-61. doi: 10.1210/jc.2015-3754.
  24. Емельянова А.Ю., Зиновьева О.Е. Витамин В12 в лечении заболеваний нервной системы. РМЖ. 2016;24(7):429-33.
  25. Gianazza E., Veber D., Eberini I., et al. Cobalamin (vitamin B12)-deficiency-induced changes in the proteome of rat cerebrospinal fluid. Biochem J. 2003;374(Pt. 1):239-46. Doi: 10.1042/ BJ20030059

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