Retrospective evaluation of the experience of using methotrexate in the treatment of ectopic pregnancy

Background. Ectopic pregnancy (EP) occurs with a frequency of 11 to 16 per 1000 pregnancies [3], the main site of localization of ectopic pregnancy is the fallopian tube (90-95% of cases) [1], and the main method of treating tubal pregnancy is surgery, more often radical surgery - salpingectomy, which leads to a decrease in the woman's reproductive potential. The use of methotrexate in the treatment of EP can significantly reduce the frequency of surgical interventions and preserve the reproductive function of women, which is important due to the difficult demographic situation in the Russian Federation. Objective. Analysis and evaluation of the effectiveness of methotrexate in drug treatment of patients with EP. Methods. A retrospective clinical study based on the analysis of case histories of 40 patients of the gynecological department of the Regional Perinatal Center, who were diagnosed with an ectopic pregnancy and were treated with methotrexate from 2017 to 2019 was carried out. Results. Of 40 patients with EP, 8 received dual administration of methotrexate and one - triple one due to the ineffectiveness of the 1st dose. One patient underwent surgery due to persistent pain syndrome. In other cases, treatment with methotrexate was effective, without significant side effects and complications. The mean hospital stay for women was 9.5 bed-days. Conclusion. With correct selection of patients, methotrexate has shown high efficacy in the treatment of WEPB with a minimum number of complications and side effects. EP treatment with methotrexate is an alternative to surgical interventions in many cases.

ectopic pregnancy, chorionic gonadotropin, ultrasonic scanning, methotrexate