Promising directions for the development of photosensitizers for photodynamic therapy


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Abstract

To date, the successes and prospects of photodynamic therapy (PDT) are of particular interest for dermatologists and cosmetologists due to the development of new generations of photosensitizers (PS), which could improve the quality of PDT and, if possible, enhance the effectiveness and safety of the method. For each of the areas, quite different requirements for the new FS are relevant. So, for the treatment of infectious diseases, it is important to minimize the risk of developing the pathogen resistance; for the treatment of neoplastic diseases - to increase the selectivity of therapy. Among the substances with the indicated properties, new active substances are being searched for. For the correction of involutional changes in the skin, PS minimizing oxidative stress accompanying the process of photoaging and the PDT procedure itself, is relevant. In recent years, similar properties have been observed in PS of natural origin, vitamins, in particular ascorbic acid. PSs of natural origin are of particular interest due to the economic attractiveness of their isolation from natural raw materials, as well as by their partial synthesis from natural starting materials. The article describes new PSs and the effects that can be obtained with their application. The issues of enhancing the effectiveness of external PSs by conjugating them with various molecules are also discussed.

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About the authors

Maria A. Beimanova

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Email: beimanova@mail.ru
Postgraduate Student Moscow, Russia

V. V Petunina

Pirogov Medical University

Moscow, Russia

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