Injection bioreparation is a promising direction in the treatment of involutional skin changes


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Skin aging is a polyetiological, pathophysiological process caused by external and internal stimulating factors. Pharmaceutical companies conduct numerous studies and create new drugs aimed at restoring skin functions. Synthetic peptides based on natural analogs have become an alternative to hyaluronic acid-based drugs. The biorestructuring agent containing Wharton’s Jelly Peptide P199 has an enhanced therapeutic potential through exclusive synergistic ingredients. The drug is the first original peptide-containing biorestructuring agent that restores the cell pool in aging skin more effectively than classical biorevitalizants. The main result - skin rejuvenation and repair - is achieved after a course of medication and lasts for a long time.

Full Text

Restricted Access

About the authors

K. V Kozhina

Premierpharm Company

Moscow, Russia

A. A Grigorieva

Premierpharm Company

Moscow, Russia

Elena V. Svechnikova

Polyclinic № 1 of the Administrative Department of the President of the Russian Federation

Email: elene-elene@bk.ru
Dr. Sci. (Med.), Head of the Department of Dermatovenereology and Cosmetology Moscow, Russia

References

  1. Winter M.C., Bickenbach J.R. Aging epidermis is maintained by changes in transit-amplifying cell kinetics, not stem cell kinetics. J Invest Dermatol. 2009; 129(11):2541-43. Doi: 10.1038/ jid.2009.236.
  2. Giangreco A., Qin M., ot al. Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell. 2008;7(2):250-59. doi: 10.1111/j.1474-9726.2008.00372.x.
  3. Jahoda C.B, Reynolds A.J. Hair follicle dermal sheath cells: unsung participants in wound healing. Lancet. 2001;358(9291):1445-48. doi: 10.1016/S0140-6736(01)06532-1.
  4. Терских В.В., Васильев А.В., Воротеляк Е.А. Ниши стволовых клеток. Известия РАН. Серия: Биология. 2007;(3):261-72
  5. Itskovitz-Eldor J., Schuldiner M., Karsenti D., at al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med. 2000;6(2):88-95.
  6. Blanpain C., Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol. 2009;10(3):207-17. doi: 10.1038/nrm2636.
  7. Chen S., Lewallen M., Xie T. Adhesion in the stem cell niche: biological roles and regulation. Development. 2013;140(2):255-65. doi: 10.1242/dev.083139.
  8. ZouboulisC.C.,AdjayeJ.,AkamatsuH.,Moe-BehrensG., Niemann C. Human skin stem cells and the ageing process. Exp Gerontol. 2008;43(11):986-97. doi: 10.1016/j.exger.2008.09.001.
  9. Автандилов ГГ Диагностическая медицинская плоидометрия. М., 2006. [Avtandilov G.G. Diagnostic medical ploidometry. M., 2006. (In Russ.)].
  10. Шехватова А.С., Дурнова А.О., Кветной И.М., Смирнова И.О. Экспрессия сигнальных молекул под действием пептида Р199 в составе препарата Meso-Wharton P199™. Инъекционные методы в косметологии. 2013;4:38-46.
  11. Кожина К.В., Волкова Е.Н., Сабурина И.Н. и др. Изучение влияния пептидных биорегуляторов на возрастные изменения кожи в культуральной модели в 3D-формате. Российский журнал кожных и венерических болезней. 2016;19(1):58-63
  12. Кожина К.В., Волкова E.H., Сабурина И.Н. и др. Meso-Wharton P199™: экспериментальное обоснование механизмов anti-age влияния препарата на модели культур дермальных фибробластов. Метаморфозы. 2016;13:64-70
  13. Петриковский Б.М. Клеточное обновление возрастной кожи как результат пептидной регуляции активности собственных стволовых клеток. Эстетическая медицина. 2012;XI(2):283-93

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2021 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies