Evolution of the concept of gluten-related diseases in children: from understanding to action


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Resumo

According to modern concepts, celiac disease is a chronic, genetically determined autoimmune T-cell-mediated enteropathy, characterized by persistent intolerance to specific proteins of the endosperm of the grain of some cereals with the development of atrophic enteropathy and the associated malabsorption syndrome. The disease has a systemic (multi-organ) nature of the autoimmune process, which determines an integrated approach to its diagnosis. In addition, the existence of non-celiac forms of gluten intolerance has been proven, which complicates the diagnostic process and the development of an adequate therapy strategy. The review presents the evolution of views on gluten-related diseases in children.

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Sobre autores

M. Gurova

Saint Petersburg State Pediatric Medical University

Email: gas-tropedclin@gmail.com
Saint Petersburg, Russia

A. Khavkin

Veltischev Research and Clinical Institute of Pediatrics; Pirogov Russian National Research Medical University

Moscow, Russia

V. Novikova

Saint Petersburg State Pediatric Medical University

Saint Petersburg, Russia

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