Possibilities of using anti-cytokine drugs for inflammatory dermatoses in HIV-positive patients


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Abstract

The use of anticytokine drugs for the reversible blocking of an overproduction of certain cytokines is a highly promising direction in medicine. In particular, the use of targeted therapy for inflammatory dermatoses requiring systemic treatment is also in this direction. At the same time, the immunological features of the course of inflammatory dermatoses in HIV-infected patients remain a poorly studied issue. The review article analyzes the identified immunological features in patients with inflammatory dermatoses (psoriasis, atopic dermatitis, seborrheic dermatitis) with HIV infection, describes possible common points of application of modern biological drugs aimed at treating inflammatory dermatoses, taking into account the possible impact on the course of HIV infection. In addition, the authors ask about the effect of the ongoing anticytokine therapy of autoimmune dermatoses in HIV-infected patients on a possible change in the sensitivity and effectiveness of antiretroviral therapy in this category of patients. It is known that from 5 to 30% of HIV-infected patients practically do not respond to antiretroviral therapy. As an example of the effectiveness of the treatment of inflammatory dermatoses, the experience of using interleukin blockers in a limited number of foreign publications is presented.

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About the authors

Evgeny Yu. Evdokimov

Central Research Institute of Epidemiology

Email: evdokimovevg@yandex.ru
Cand. Sci. (Med.), Researcher at the Clinical Department Moscow, Russia

Zh. B Ponezheva

Central Research Institute of Epidemiology

Moscow, Russia

E. V Svechnikova

Polyclinic №1 of the Administrative Department of the President of the Russian Federation; Novosibirsk State Medical University

Moscow, Russia

A. V Sundukov

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Moscow, Russia

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