Change in the epidermal and dermal thickness as a result of photodynamic therapy using chlorin E6


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Abstract

Background. Due to the active rhythm of life and the increase in life expectancy, the demand for non-injection methods for correcting age-related skin changes is growing. Photodynamic therapy (PDT) methods, in particular, with the use of chlorin E6 derivatives, are increasingly used in cosmetology clinics. Objective. Evaluation of the effect of PDT with the use of chlorin E6-based photosensitizers and light radiation with a wavelength of 410 and 630 nm on the thickness of the epidermis and dermis of the face immediately after treatment, as well as in the long-term period. Methods. The epidermal and dermal thickness in the facial area was determined in women aged 35 to 45 before therapeutic exposure (course of PDT procedures using chlorin E6 once a week No. 5) - immediately after, and after 3 and 6 months, compared with the control group aged 25 to 35. Results. The epidermal thickness at the end of the course of treatment increased by 12%, and the dermal thickness - by 9.2%, after 3 months - by 21.2 and 20.7%, respectively, and after 6 months - by 23 and 24.7%, respectively. As a result of PDT, the indicators in the 35-45-year-old group became comparable to those in the 25-35-year-old control group. Conclusion. The data obtained indicate an increase in the epidermis and dermal thickness as a result of PDT using chlorin E6 and make it possible to recommend this method for the correction and prevention of involutive skin changes.

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About the authors

S. I Surkichin

Central State Medical Academy of Department of Presidential Affairs

Lyudmila S. Kholupova

Central State Medical Academy of Department of Presidential Affairs

Email: karsekals@gmail.com
Teaching Assistant

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