The role of prebiotics in the formation of the microbiome in children of the first year of life


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Abstract

A number of factors influence the initial microbial colonization of the neonatal intestine, including mode of delivery, diet, antibiotic therapy, and gestational age. The development of the microbiota in an infant occurs mainly under the influence of mother’s milk. Lacto-and bifidobacteria are the main representatives of the human intestinal microbiota. In the human gastrointestinal tract, quite complex interactions between the intestinal mucosal epithelial barrier, immune cells, microbiota, and environmental factors occur. Prebiotics can also directly affect the composition of the intestinal microbiota. To date, the most commonly used and studied prebiotics are galac-tooligosaccharides, polydextrose, fructooligosaccharides, inulin, etc. An important stage in the development of intestinal microbiota diversity in children is the expansion of food diversity.

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About the authors

Svetlana B. Krutikhina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: svetulkakru@gmail.com
Cand. Sci. (Med.), Teaching Assistant at the Department of Children’s Diseases, N.F. Filatov Clinical Institute of Children's Health

E. A Yablokova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

L. A Galstyan

I.M. Sechenov First Moscow State Medical University (Sechenov University)

A. V Gorelov

Central Scientific Research Institute of Epidemiology

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