Problem of treatment adherence in patients with type 2 diabetes mellitus


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Patients with type 2 diabetes mellitus (DM2) are advised to keep a healthy diet and increase physical activity in addition to taking antidiabetic drugs. To prevent complications associated with diabetes, drugs to control blood pressure and dyslipidemia are also included in the treatment regimen. Despite expanding treatment options every year, studies show that less than 50% of patients reach their targets. Most often this is due to low adherence of patients to treatment. Treatment adherence is the degree to which a person’s behavior - taking medication, following diet, and executing lifestyle changes - corresponds to recommendations. The first part of the review discusses the factors that reduce adherence to DM drug therapy and possible strategies for improving adherence (modification of drug prescribing regimens, methods of their administration; the use of educational programs to improve communication between the doctor and the patient). The second part of the review discusses ways to improve adherence to non-pharmacological treatments for DM2 (lifestyle modifications) and build sustainable treatment motivation. All the strategies for improving patient adherence described in the review have proven efficacy and should be included in routine clinical practice.

Full Text

Restricted Access

About the authors

A. D Akulova

Pirogov Russian National Research Medical University

Yu. S Zhulina

Pirogov Russian National Research Medical University

V. V Rozhkova

Pirogov Russian National Research Medical University

E. Yu Martynova

LLC “Relevant medicine"

Yury E. Poteshkin

Pirogov Russian National Research Medical University

Email: dr.yep@ya.ru
Cand. Sci. (Med.), Associate Professor, Department of Endocrinology, Faculty of General Medicine

References

  1. International Diabetes Federation. IDF Diabetes Atlas,10-th edition, 2021 URL: https://diabetesatlas.org/ (Access date: 15.03.2022).
  2. Дедов И.И., Шестакова М.В., Викулова О.К., и др.Эпидемиологические характеристики сахарногодиабета в Российской Федерации: клинико-статистический анализ по данным регистра сахарного диабета на 01.01.2021. Сахарный диабет.2021;24(3):204-21. doi: 10.14341/DM12759.
  3. Leon B.M., Maddox T.M. Diabetes and cardiovasculardisease: Epidemiology, biological mechanisms,treatment recommendations and future research.World J Diabetes. 2015;6(13):1246-58. doi: 10.4239/wjd.v6.i13.1246.
  4. World Health Organization. WHO LibraryCataloguing-in-Publication Data. Adherence tolong-term therapies: evidence for action. 2003.URL: https://www.who.int/chp/knowledge/publications/adherence_full_report.pdf
  5. Khunti N., Khunti N., Khunti K. Adherenceto type 2 diabetes management. Br J Diabetes.2019;19(2):99-104. doi: 10.15277/bjd.2019.223.
  6. Heikkala E., Mikkola I., Jokelainen J., et al.Multimorbidity and achievement of treatment goalsamong patients with type 2 diabetes: a primarycare, real-world study. BMC Health Serv Res.2021;21(1):964. doi: 10.1186/s12913-02106989-x.
  7. Gonzalez Heredia T., González-Ramírez L.P.,Hernández-Corona D.M., Maciel-Hernández E.A.Anxious depression in patients with Type 2Diabetes Mellitus and its relationship withmedication adherence and glycemic control.Global Public Health. 2021;16(3):460-68. doi: 10.1080/17441692.2020.1810735
  8. Hashimoto K., Urata K., Yoshida A., et al. Therelationship between patients’ perception of type2 diabetes and medication adherence: a crosssectionalstudy in Japan. Journal of PharmaceuticalHealth Care and Sciences. 2019;5:2. doi: 10.1186/s40780-019-0132-8.
  9. Urata K., Hashimoto K., Horiuchi R., et al. Impactof Diabetes Perceptions on Medication Adherencein Japan. Pharmacy (Basel). 2019;7(4):144. Doi:10. 3390/pharmacy7040144.
  10. Majeed A., Rehman M., Hussain I., et al. The Impactof Treatment Adherence on Quality of Life AmongType 2 Diabetes Mellitus Patients-Findings froma Cross-Sectional Study. Patient Prefer Adherence.2021;15:475. doi: 10.2147/PPA.S295012.
  11. Chaveepojnkamjorn W., Pichainarong N., Schelp F.P.,Mahaweerawat U. Quality of life and complianceamong type 2 diabetic patients. Southeast Asian JTrop Med Public Health. 2008;39(2):328-34.
  12. Wahyuni Y. Improving The Quality of Life of Patients with Diabetes Mellitus Type 2 withTreatment Adherence. Media KeperawatanIndonesia. 2021;4(3):234-46. doi: 10.26714/mki.4.3.2021.234-46.
  13. Peyrot M., Barnett A.H., Meneghini L.F., SchummDraeger P.M. Factors associated with injectionomission/non-adherence in the Global Attitudesof Patients and Physicians in Insulin Therapy study.Diabetes Obes Metab. 2012;14(12):1081-87.doi: 10.1111/j.1463-1326.2012.01636.x.
  14. Psarou A., Cooper H., Wilding, J. Patients’Perspectives of Oral and Injectable Type 2 Diabetes Medicines, Their Body Weight and Medicine-Taking Behavior in the UK: A Systematic Review and MetaEthnography. Diabetes Ther. 2018;9(5):1791. doi: 10.1007/s13300-018-0490-5.
  15. Modi K.D., Farishta F., Phatak S., et al. Adherenceand Swallowing Experience with a Modified,Smaller-sized Tablet Formulation of Metforminand Glimepiride (SR) in Indian Patients with Type2 Diabetes Mellitus. J Assoc Physicians India.2019;67(12):44-9.
  16. Paes A.H., Bakker A., Soe-Agnie C.J. Impact ofdosage frequency on patient compliance. Diabetes Care. 1997;20(10):1512-17. doi: 10.2337/diacare.20.10.1512.
  17. Böhm A.K., Schneider U., Aberle J., Stargardt, T.Regimen simplification and medication adherence:Fixed-dose versus loose-dose combination therapy fortype 2 diabetes. PloS one. 2021;16(5):e0250993.doi: 10.1371/journal.pone.0250993.
  18. Qiao Q., Ouwens M.J., Grandy S., et al. Adherenceto GLP-1 receptor agonist therapy administeredby once-daily or once-weekly injection in patientswith type 2 diabetes in Germany. Diabete, Metab Syndr Obes. 2016;9:201-5. doi: 10.2147/DMSO.S99732.
  19. Петунина Н.А., Трухина Л.В., Синицына Е.И.,Анциферов, М.Б. Преимущества метформина пролонгированного действия. Фарматека,2013;(5):81-85. [Petunina N.A., Trukhina L.V.,Sinitsyna E.I., Antsiferov M.B. Benefits of long actingmetformin. Farmateka. 2013;(5):81-5. (In Russ.)].
  20. Wang Y., Zeng Z., Ding J., et al. Fear of hypoglycaemiaamong patients with type 2 diabetes mellitus: across-sectional study. Sci Rep. 2021;11(1):1-8.doi: 10.1038/s41598-021-86954-0.
  21. Alwhaibi M., Balkhi B., Alhawassi T.M., et al.Polypharmacy among patients with diabetes: a crosssectionalretrospective study in a tertiary hospital inSaudi Arabia. BMJ Open. 2018;8(5):e020852. doi: 10.1136/bmjopen-2017-020852.
  22. Horii T., Iwasawa M., Kabeya Y., Atuda K.Polypharmacy and oral antidiabetic treatment fortype 2 diabetes characterised by drug class andpatient characteristics: A Japanese database analysis.Sci Rep. 2019;9(1):1-6. doi: 10.1038/s41598019-49424-2.
  23. Martin L.R., Williams S.L., Haskard K.B., Dimatteo M.R. The challenge of patient adherence. Ther ClinRisk Manag. 2005;1(3):189-99.
  24. Durmuş A., Akbolat M. The impact of patientsatisfaction on patient commitment and the mediatingrole of patient trust. J Patient Exp. 2020;7(6):1642-1647. doi: 10.1177/2374373520967807
  25. Grant R.W., Devita N.G., Singer D.E., Meigs J.B. Polypharmacy and medication adherencein patients with type 2 diabetes. DiabetesCare. 2003;26(5):1408-12. doi: 10.2337/diacare.26.5.1408.
  26. Odgers-Jewell K., Ball L.E., Kelly J.T., et al.Effectiveness of group-based self-managementeducation for individuals with Type 2 diabetes: asystematic review with meta-analyses and metaregression.Diabetic Med. 2017;34(8):1027-39.doi: 10.1111/dme.13340.
  27. Fan M.H., Huang B.T., Tang Y.C., et al. Effect ofindividualized diabetes education for type 2 diabetesmellitus: a single-center randomized clinical trial.African health sciences. 2016;16(4):1157-62.doi: 10.4314/ahs.v16i4.34.
  28. Singer J., Levy S., Shimon I. Group versus individualcare in patients with long-standing type 1 and type 2diabetes: a one-year prospective noninferiority studyin a tertiary diabetes clinic. J Diabetes Res. 2018.doi: 10.1155/2018/1807246. URL: https://www.hindawi.com/journals/jdr/2018/1807246/
  29. Ноздрачев Д.И., Замятин К.А., Таратухин Е.О.Цифровые средства повышения приверженности к лечению. Российский кардиологическийжурнал. 2019;(12):96-102. [Nozdrachev D.I.,Zamyatin K.A., Taratukhin E.O. Digital toolsfor improving medication adherence. Rossiiskiikardiologicheskii zhurnal=Russian Journal ofCardiology. 2019;(12):96-102. (In Russ.)]. doi: 10.15829/1560-4071-2019-12-96-102.
  30. Шадеркин, И.А., Шадеркина, В.А. Удаленныймониторинг здоровья: мотивация пациентов.Российский журнал телемедицины и электронного здравоохранения. 2020;6(3):36-43.[Shaderkin I.A., Shaderkina V.A. Remote healthmonitoring: motivating patients. Rossiiskii zhurnaltelemeditsiny i elektronnogo zdravookhraneniya=Кгыышфт Journal of Telemedicine andE-Health. 2020;6(3):37-43. (In Russ.)]. doi: 10.29188/2542-2413-2020-6-3-37-43.
  31. Boyels O. How to Prevent Burnout as a Healthcare Professional. Icanotes. 2019. URL: https://www.icanotes.com/2019/04/22/how-to-preventburnoutas-a-healthcare-professional/ (Access date 03.2022).
  32. Lewin E. Professional coaching can reduce burnoutin doctors. NewsGP. 2019. URL: https://www1.racgp.org.au/newsgp/clinical/professionalcoachingcan-reduce-burnout-in-doctor (Accessdate 15.03.2022).
  33. Волкова Е.А., Малыгина О.Ф. Сахарный диабет исердечно-сосудистые заболевания. Актуальныйподход к модификации образа жизни и лечению пациентов с сахарным диабетом 2-готипа. Consilium Medicum.2019;21(1):74-80.[Volkova E.A, Malygina O.F. Diabetes mellitus andcardiovascular diseases. An updated approach tolifestyle modification and treatment of patientswith diabetes mellitus type 2. Consilium Medicum.2019;21(1):74-80. (In Russ.)]. doi: 10.26442/20751753.2019.1.190273.
  34. Lim G.Y. Low-calorie diet and exercise put diabetesin remission for 60% of patients: Qatar RCT.Food navigator-asia. 2020. URL: https://www.foodnavigator-asia.com/Article/2020/06/03/Low-calorie-diet-and-exercise-put-diabetes-inremissionfor-60-of-patients-Qatar-RCT (Accessdate 15.03.2022).
  35. Лиходей Н.В., Калашникова М.Ф., Лиходей Е.М.,Фадеев, В.В. Анализ факторов, препятствующих формированию приверженности лечениюсреди больных сахарным диабетом, и стратегий, способствующих ее повышению. Сахарныйдиабет, 2018;21(1):5-14. [Likhodey N.V.,Kalashnikova M.F., Likhodey E.M., Fadeyev V.V.Analysis of the factors that prevent adherence totreatment in patients with diabetes mellitus andthe strategies that contribute to the improvementin adherence. Sakharnyi diabet=Diabetes mellitus.2018;21(1):5-14. (In Russ.)]. doi: 10.14341/DM8781.
  36. Опросник по здоровью EQ-5D. Версия нарусском языке для России. URL: https://spb.hse.ru/data/2020/03/10/1563014698/EQ-5D-3L.pdf (Дата обращения: 15.03.2022).
  37. Алкишиева С.М., Асланова Г.Д., Долдаева С.А., идр. Анализ качества жизни больных, страдающихСД 2 типа, в ГП№ 1 г. Алматы. Вестник КазахскогоНационального медицинского университета.2020;(2-1):468-470.
  38. Аметов А.С., Валитов Б.И., Черникова Н.А.Терапевтическое обучение больных: прошлое, настоящее, будущее. Сахарный диабет. 2012;(1):71-77. [Ametov A.S., Valitov B.I.,Chernikova N.A. Therapeutic training: past, presentand future. Sakharnyi diabet=Diabetes Mellitus.2012;(1):71-7. (In Russ.)]
  39. Иванова Е.Н., Светлова О.В. Роль семьи в социально-психологической реабилитации и абилитации инвалидов на примере Школы сахарногодиабета. Вестник науки и образования. 2020;(91 (87)):85-92. [Ivanova E.N., Svetlova O.V. Therole of family in socio-psychological rehabilitationand habilitation of persons with disabilitieson the example of schools of diabetes. Vestniknauki i obrazovaniya. 2020;(9-1 (87)):85-92.(In Russ.)]
  40. Голубев В.Л., Данилов, А.Б. Добрушина О.Р.Применение стратегии повышения мотивации пациента в лечении хронической боли.Русский медицинский журнал. Специальныйвыпуск. Болевой синдром.2011;1-5.
  41. Norcross J.C., Krebs P.M., Prochaska J.O. Stages ofchange. J Clin Psychol.2011;67(2):143-54. doi: 10.1002/jclp.20758.
  42. Вакнин Е.Е. Психологические технологии формирования приверженности лечению и реабилитации наркозависимых: практическое пособие.М., 2018. [Vaknin E.E. Psychological technologiesfor the formation of adherence to the treatment andrehabilitation of drug addicts: a practical guide. М.,2018. (In Russ.)].

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2022 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies