Maternal sepsis: a new international definition - new opportunities to improve outcomes


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Abstract

Background. Maternal sepsis is an interdisciplinary problem that determines the perinatal and maternal mortality level worldwide. A unified terminology makes it possible to unify tactics in the diagnosis, therapy and management of pregnant women, women in childbirth and puerperas, contributing to improved outcomes. The review presents epidemiological data on the structure of obstetric sepsis in recent years in the world, which is one of the main causes of maternal mortality (11% - on average, 3.6% - in Russia), the newly emerging causes of its growth (an increase in the number of births in megacities, their concentration in large obstetric institutions and an increase in the caesarean section rate), social significance and unresolved problems for countries with any level of economy, such as the lack of a clear definition of maternal sepsis, its criteria, and therefore, inaccuracies in epidemiological estimates, delays in timely diagnosis and treatment. Conclusion. The development of standardized diagnostic criteria for maternal sepsis according to the changes commonly found in pregnancy will facilitate high effective strategies for reduction of the impact of these conditions on maternal health worldwide.

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About the authors

N. A Gabitova

Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA

Email: gabitova_nataliya@mail.ru
Moscow, Russia

A. G Kedrova

Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA

Moscow, Russia

M. A Zakharova

Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA

Moscow, Russia

T. N Belousova

Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA

Moscow region, Vidnoye, Russia

O. N Kucherova

Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA

Moscow, Russia

References

  1. Say L., Chou D., Gemmill A., et al. Global causes of maternal death: a WHO systematic analysis. Lancet. Glob Health. 2014;2(6):e323-33. doi: 10.1016/S2214-109X(14)70227-X.
  2. The American College of Obstetricians and Gynecologists. ACOG Committee Opinion. Optimizing postpartum care. Obstet Gynecol. 2018;131(5):e140-50. Doi: 10.1097/ aog.000000000002633.
  3. Lowe N.K. Reconsidering postpartum care. JOGNN. 201;48:1-2. doi: 10.1016/j.jogn.2018.12.001.
  4. Tully K.P, Stuebe A.M., Verbiest S.B. The fourth trimester: a critical transition period with unmet maternal health needs. Am J Obstet Gynecol. 2017;37-41. doi: 10.1016/j.ajog.2017.03.032.
  5. Chan G.J., et al. Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis. PLoS Med. 2013;10(8):e1001502. Doi: 10.1371/ journal.pmed.1001502.
  6. Ali A, Lamont R.F Recent advances in the diagnosis and management of sepsis in pregnancy. F1000Res. 2019;8:F1000. Doi: 10.12688/ f1000research.18736.1
  7. Singer M., Deutschman C.S., Seymour C.W., et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-10. Doi: 10.1001/ jama.2016.0287.
  8. Acosta C.D., Knight M. Sepsis and maternal mortality. Curr Opin Obstet. Gynecol. 2013;25(2): 109-16. Doi: 10.1097/ GCO.0b013e32835e0e82.
  9. Bauer M.E., Bauer S.T, Rajala B., et al. Maternal physiologic parameters in relationship to systemic inflammatory response syndrome criteria: a systematic review and meta-analysis. Obstet Gynecol. 2014;124(3):535-41. Doi: 10.1097/ AOG.0000000000000423.
  10. van Dillen J., Zwart J., Schutte J., et al. Maternal sepsis: epidemiology, etiology and outcome. Curr Opin Infect Dis. 2010;23(3):249-54. doi: 10.1097/QCO.0b013e328339257c.
  11. Royal College of Obstetricians and Gynaecologists. Sepsis in Pregnancy, Bacterial (Green-top Guideline No. 64a); 2012. URL: https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg64a/. Accessed 10 Feb 2017
  12. Kramer H.M., Schutte J.M., Zwart J.J., et al. Maternal mortality and severe morbidity from sepsis in the Netherlands. Acta Obstet Gynecol Scand. 2009;88(6):647-53. doi: 10.1080/00016340902926734.
  13. Anderson B.L. Puerperal group a streptococcal infection: beyond semmelweis. Obstet Gynecol. 2014;123(4):874-82. Doi: 10.1097/ AOG.0000000000000175.
  14. Lumbiganon P., et al. Indirect causes of severe adverse maternal outcomes: a secondary analysis of the WHO multicountry survey on maternal and newborn health. BJOG. 2014;121(Suppl. 1):32-9. doi: 10.1111/1471-0528.12647.
  15. Cantwell R., Clutton-Brock T., Cooper G., et al. Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG. 2011;118(Suppl. 1):1-203. doi: 10.1111/j.1471-0528.2010.02847.x.
  16. Материнская смертность в Российской Федерации в 2014 г. (методическое письмо). Под ред. Е.Н. Байбариной. М., 2015. 73 с. @@Maternal mortality in the Russian Federation in 2014 (methodological letter). Ed. by E.N. Baibarina. M., 2015. 73 p. (In Russ.).
  17. Buddeberg B.S., Aveling W. Puerperal sepsis in the 21st century: progress, new challenges and the situation worldwide. Postgrad Med J. 2015;91(1080):572- 78. Doi: 10.1136/ postpradmedj-2015-133475.
  18. Morgan J., Roberts S. Maternal sepsis. Obstet Gynecol Clin North Am. 2013;40(1):69-87. doi: 10.1016/j.ogc.2012.11.007.
  19. Barton J.R., Sibai B.M. Severe sepsis and septic shock in pregnancy. Obstet Gynecol. 2012;120(3):689-706. Doi: 10.1097/ AOG.0b017e718267a52d.
  20. Oud L. Pregnancy-associated severe sepsis: contemporary state and future challenges. Infect Dis Ther. 2014;3(2):175-89. Doi: 10.1007/ s40121-014-0037-7.
  21. Dolea C., Stein C. Global burden of maternal sepsis in the year 2000. World Health Organization: 2003. Accessed 10 Feb 2017. Doi: 10.1186/ s12978-017-0437-8.
  22. Bone R.C., Balk R.A., Cerra F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/ SCCM consensus conference committee. American college of chest physicians/society of critical care medicine. Chest. 1992;101(6):1644-55. doi: 10.1378/chest.101.6.1644.
  23. Levy M.M., Fink M.P, Marshall J.C., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference.Intensive Care Med. 2003;29(4):530-38. doi: 10.1007/s00134-003-1662-x.
  24. Dellinger R.P., Levy M.M., Rhodes A., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.
  25. Bonet M, Nogueira Pileggi V., Rijken M.J., et al. The Global Maternal and Neonatal Sepsis Initiative Working Group, Towards a consensus definition of maternal sepsis: results of a systematic review and expert consultation. Reprod Health. 2017;14(1):67. doi: 10.1186/s12978-017-0321-6.
  26. Kendle A.M., Salemi J.L., Tanner J.P., Louis J.M. Delivery-associated sepsis: trends in prevalence and mortality. Am J Obstet Gynecol. 2019;220(4): e391-391. doi: 10.1016/j.ajog.2019.02.002.
  27. Yokoe D.S., Christiansen C.L., Johnson R., et al. Epidemiology of and surveillance for postpartum infections. Emerg Infect Dis. 2001;7(5):83-41. doi: 10.3201/eid0705.010511.
  28. Hensley M.K., Bauer M.E., Admon L.K., et al. Incidence of Maternal Sepsis and Sepsis-Related Maternal Deaths in the United States. JAMA. 2019;322(9):890-92. Doi: 10.1001/ jama.2019.9818.
  29. Kuklina E.V, Whiteman M.K., Hillis S.D., et al. An enhanced method for identifying obstetric deliveries: implications for estimating maternal morbidity. Matern Child Health J. 2008;12(4):469-77. doi: 10.1007/s10995-007-0256-6.
  30. Saccone G., Berghella V. Antibiotic prophylaxis for term or near-term premature rupture of membranes: metaanalysis of randomized trials. Am J Obstet Gynecol. 2015;212(5):627-29. doi: 10.1016/j.ajog.2014.12.034.
  31. Organizacion de los estados americanos.Introduccion: La desigualdad y la pandemia del COVID-19 en las Americas. In: Organizacion de los estados americanos. Guia Practica de Respuestas Inclusivas y con Enfoque de Derechos ante el COVID-19 en las Americas. Washington, DC: OEA, 2020. 103 p. [cited 2020 Sep 15]. URL: http://www.oas.org/es/sadye/publicaciones/GUIA_SPA.pdf
  32. The American College of Obstetricians and Gynecologists. ACOG Committee Opinion. Optimizing postpartum care. Obstet Gynecol. 2018;131(5):e140-50. Doi: 10.1097/ aog.000000000002633.
  33. Chou D., et al. Constructing maternal morbidity -towards a standard tool to measure and monitor maternal health beyond mortality. BMC. Pregnancy Childbirth. 2016;16:45. doi: 10.1186/s12884-015-0789-4.
  34. Kourtis A.P., Read J.S., Jamieson D.J. Pregnancy and infection. N Engl J Med. 2014;370(23):2211-doi: 10.1056/NEJMra1213566.
  35. Barton J.R., Sibai B.M. Severe sepsis and septic shock in pregnancy. Obstet Gynecol. 2012;120(3):689-706. Doi: 10.1097/ AOG.0b013e318263a52d.
  36. Allen V.M., O’Connell C.M., Liston R.M., Baskett TF Maternal morbidity associated with cesarean delivery without labor compared with spontaneous onset of labor at term. Obstet Gynecol. 2003;102(3):477-82. doi: 10.1097/01. aog.0000215988.23224.e4.
  37. Tharpe N. Postpregnancy genital tract and wound infections. J Midwifery Womens Health. 2008;53(3):236-46. Doi: 10.1016/j. jmwh.2008.01.007.
  38. Chan G.J., Lee A.C., Baqui A.H., et al. Risk of early -onset neonatal infection with maternal infection or colonization: a global systematic review and metaanalysis. PLoS Med. 2013;10(8):e1001502. doi: 10.1371/journal.pmed.1001502.
  39. Bellizzi S., Bassat Q., Ali M.M., et al. Effect of puerperal infections on early neonatal mortality: a secondary analysis of Six demographic and health surveys. PLoS One. 2017;12(1):e0170856. doi: 10.1371/journal.pone.0170856.
  40. The American College of Obstetricians and Gynecologists. ACOG Committee Opinion. Optimizing postpartum care. Obstet Gynecol. 2018;131(5):e140-50. Doi: 10.1097/ aog.000000000002633.
  41. Edwards S.E., Grobman W.A., Lappen J.R., et al. Modified obstetric early warning scoring systems (MOEWS): validating the diagnostic performance for severe sepsis in women with chorioamnionitis. Am J Obstet Gynecol. 2015;212(4):e5361-68. doi: 10.1016/j.ajog.2014.11.007.
  42. Aarvold A.B., Ryan H.M., Magee L.A., et al. Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients. Crit Care Med. 2016;45(1):e49-57. doi: 10.1097/CCM.0000000000002018.
  43. Escobar M.F., Echavarria M.P, Zambrano M.A., et al. Maternal sepsis. Am J Obstet Gynecol. MFM. 2020;2(3):100149. Doi: 10.1016/j. ajogmf.2020.100149. Поступила / Received: 11.05.2022 Принята в печать / Accepted: 06.06.2022

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