Predictive and prognostic role of tumor-infiltrating lymphocytes (TILs) in early triple-negative breast cancer


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Abstract

Currently, there are no reliable strategies for personalizing the treatment of patients with early-stage triple-negative breast cancer (TNBC). The advent of immune checkpoint inhibitors in modern oncology has significantly improved survival in some cancers. New evidence suggests that tumor-infiltrating lymphocytes (TILs) are associated with response to both chemotherapy and immunotherapy in patients with TNBC. Why hasn’t such a simple and cheap biomarker as TILs entered into routine practice? There are still problems to be solved.

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About the authors

Sh. R Abdulaeva

N.N. Petrov National Medical Research Center of Oncology

Petersburg, Russia

Tatyana Yu. Semiglazova

N.N. Petrov National Medical Research Center of Oncology; North-Western State Medical University n.a. I.I. Mechnikov

Email: tsemiglazova@mail.ru
Dr. Sci. (Med.), Associate Professor, Head of the Department, Leading Researcher at the Research Department of Innovative Methods of Therapeutic Oncology and Rehabilitation; Professor at the Department of Oncology Petersburg, Russia; Petersburg, Russia

A. S Artemyeva

N.N. Petrov National Medical Research Center of Oncology

Petersburg, Russia

A. G Kudaibergenova

N.N. Petrov National Medical Research Center of Oncology

Petersburg, Russia

S. M Sharashenidze

N.N. Petrov National Medical Research Center of Oncology

Petersburg, Russia

A. I Tseluyko

N.N. Petrov National Medical Research Center of Oncology

Petersburg, Russia

R. M Paltuev

N.N. Petrov National Medical Research Center of Oncology

Petersburg, Russia

V. V Semiglazov

N.N. Petrov National Medical Research Center of Oncology; Pavlov University

Petersburg, Russia; Petersburg, Russia

P. V Krivorotko

N.N. Petrov National Medical Research Center of Oncology; North-Western State Medical University n.a. I.I. Mechnikov

Petersburg, Russia; Petersburg, Russia

V. F Semiglazov

N.N. Petrov National Medical Research Center of Oncology; North-Western State Medical University n.a. I.I. Mechnikov

Petersburg, Russia; Petersburg, Russia

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