Pemphigus


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详细

Pemphigus unites a group of rare autoimmune bullous dermatoses affecting the skin and mucous membranes. The disease is characterized by a chronic severe course, leading to deterioration in the quality of life and often death. Autoantibodies that are directed against various desmosome proteins are produced, that leads histologically to intraepidermal cleavage and clinically to blistering and erosion of the mucosal and/or skin epithelium. The diagnosis of the pemphigus subtype is based on clinical signs, the level of histological segregation, and the identification of antigens recognized by circulating autoantibodies using immunoassays. The epidemiological features of pemphigus vary considerably in different regions of the world. The prognosis, mortality, and clinical outcomes of pemphigus have changed significantly over the years.

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作者简介

Elena Yunusova

Kazan State Medical Academy - Branch Campus of Russian Medical Academy of Continuous Professional Education

Email: elenaiu@mail.ru
Cand. Sci. (Med.), Associate Professor at the Department of Dermatovenereology and Cosmetology Kazan, Russia

L. Yusupova

Kazan State Medical Academy - Branch Campus of Russian Medical Academy of Continuous Professional Education

Kazan, Russia

Z. Garaeva

Kazan State Medical Academy - Branch Campus of Russian Medical Academy of Continuous Professional Education

Kazan, Russia

G. Mavlyutova

Kazan State Medical Academy - Branch Campus of Russian Medical Academy of Continuous Professional Education

Kazan, Russia

A. Galimova

Kazan State Medical Academy - Branch Campus of Russian Medical Academy of Continuous Professional Education

Kazan, Russia

参考

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