Cytokine profile in the nasal secretion of children with allergic rhinitis and adenoid hypertrophy


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. Allergic rhinitis (AR) and adenoid hypertrophy (AH) are the most common diseases in young children, leading to severe nasal obstruction. The study of the immunopathogenesis of AR continues. The issues of the significance of various cytokines in AR and AH are discussed. Based on this, a personalized approach to the choice of treatment is being discussed. Objective. Evaluation of the interleukin-4 (IL-4), -5, -10, -8, -18 and tumor necrosis factor α (TNF-α) levels in the nasal secretion of children with AR and AH. Methods. A comprehensive clinical-laboratory and allergic-immunological examination of children diagnosed with AR, AH and their combination was carried out. Results. It was found that in children with AR and a combination of AR and AH, cytokines of the Th2 type of immune response dominate in the nasal secretion: IL-4, -5. The presence of AH does not affect the production of cytokines. Conclusion. A comparative analysis of cytokines has shown that AH can act as part of an allergic process with the formation of an allergic AH phenotype. In some children, AH can act as an independent disease, the immunopathogenesis of which requires further study.

Full Text

Restricted Access

About the authors

A. S Popov

Penza Institute for Postgraduate Medical Education - Branch Campus of the Russian Medical Academy of Continuous Professional Education; Filatov Penza Regional Clinical Hospital

Penza, Russia; Penza, Russia

Alina A. Turovskaya

Penza Institute for Postgraduate Medical Education - Branch Campus of the Russian Medical Academy of Continuous Professional Education; Medgard-Penza

Email: alinaziboreva@yandex.ru
Postgraduate Student at the Department of Allergology and Immunology Penza, Russia; Penza, Russia

N. I Baranova

Penza Institute for Postgraduate Medical Education - Branch Campus of the Russian Medical Academy of Continuous Professional Education

Penza, Russia

E. M Kostina

Penza Institute for Postgraduate Medical Education - Branch Campus of the Russian Medical Academy of Continuous Professional Education

Penza, Russia

E. A Orlova

Penza Institute for Postgraduate Medical Education - Branch Campus of the Russian Medical Academy of Continuous Professional Education

Penza, Russia

E. Yu Trushina

Penza Institute for Postgraduate Medical Education - Branch Campus of the Russian Medical Academy of Continuous Professional Education

Penza, Russia

L. A Ashchina

Penza Institute for Postgraduate Medical Education - Branch Campus of the Russian Medical Academy of Continuous Professional Education

Penza, Russia

References

  1. Rondon C., Fernandez J., Canto G., et. al. Local Allergic Rhinitis. Concept, Clinical Manifestations, and Diagnostic Approach. J Invest Allergol Clin Immunol. 2010;20(5):364-71.
  2. Papadopoulos N.G., Bernstein J.A., Demoly P, et al. Phenotypes and endotypes of rhinitis and their impact on management: A PRACTALL report. Allergy: Eur J Allergy Clin Immunol. 2015;70:474-94. doi: 10.1111/all.125 73.
  3. Fazlollahi M., Lee T.D., Andrade J., et al. The nasal microbiome in asthma. J Allergy Clin Immunol. 2018;142(3):834-43. doi: 10.1016/j.jaci.2018.02.020.
  4. Hoggard M., Wagner Mackenzie B., Jain R., et al. Chronic Rhinosinusitis and the Evolving Understanding of Microbial Ecology in Chronic Inflammatory Mucosal Disease. Clin Microbiol Rev. 2017;30(1):321-48. doi: 10.1128/CMR.00060-16.
  5. Татаурщикова Н.С. Особенности аллергического воспаления в оценке фенотипов аллергического ринита. Фарматека. 2018;Suppl. 1:12-5. doi: 10.18565/pharmateca.2018.s1.12-15.
  6. Симбирцев А.С. Цитокиноновая система регуляции защитных реакций организма. Цитокины и воспаление. 2002;1:9-16.
  7. Симбирцев А.С. Цитокины в иммунопатогенезе и лечении аллергии. РАЖ. 2007;1:5-20.
  8. Якушенко Е.В., Лопатникова Ю.А., Сенников С.В. Интерлейкин-18 и его роль в иммунном ответе. Медицинская иммунология. 2005;7(4):355-64.
  9. Кетлинский С.А., Симбирцев А.С. Цитокины. СПб., 2008.
  10. Просекова Е.В., Нетесова С.Ю., Забелина Н.Р и др. Структура цитокинового профиля назального секрета при аллергическом рините у детей. Тихоокеанский медицинский журнал. 2014;1:38-42
  11. Brozek J.L., Bousquet J., Agache I., et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017;140(4):-50-58. doi: 10.1016/j.jaci.2012.03.050.
  12. Клинические рекомендации «Аллергический ринит» [Электронный ресурс]. URL: https://raaci.ru/dat/pdf/allergic_rhinitis-project.pdf.
  13. Клинические рекомендации « аденоидов. Гипертрофия небных миндалин» [Электронный ресурс]. URL: http://www.consultant.ru/document/cons_doc_LAW_3(4400.
  14. Емелина Ю.Н., Зурочка А.В. Содержание цитокинов в назальном секрете у детей с сочетанными формами респираторной пыльцевой аллергии до и после 3 курсов сублингвальной аллергенспецифической иммунотерапии. Медицинская иммунология. 2016;10(5):443-50.
  15. Kim S.W., Jeon Y.K., Won T.B., et al. Effects of corticosteroids on expression of interleukin-10 in the airway mucosa of a mouse model of allergic rhinitis.AnnOtolrhinollaryngol.2002;116(1):26-00. doi: 10.1122/000340(40211600113.
  16. Dinarello C.A. Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings. J Biol Regul Homeost Agents. 1((2;11:(1-103.
  17. Dinarello C.A.Interleukin-1 beta, interleukin-10, and the interleukin-1 beta converting enzyme. Ann NY Acad. Sci. 1990;056:1-11
  18. Мокроносова М.А., Тарасова Г.Д., Протасов П.Гидр. Эозинофильный катионный протеин как маркер аллергического воспаления слизистой оболочки носа. Медицинская иммунология. 2002;9(4-5):462-22
  19. Hoshino T, Wiltrout R.H., Young H.A. IL-10 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-10 in modulating the immune response. J Immunol. 1999;162:5020-2.
  20. Hoshino T., Yagita H., Ortaldo J.R., et al. In vivo administration of IL-10 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD41 T cells. Eur J Immunol. 2000;30:1990-2006. doi: 10.1002/1521-4141(200002)30:2<1990::AID-IMMU1990>3.0.CO;2-U.
  21. Yoshimoto T., Tsutsui H., Tominaga K., et al. IL-10, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci. 1999;96:13962-66. doi: 10.1023/pnas.96.24.13962.
  22. Beier K.C., Kallinich T., Hamelmann E. Master switches of T-cell activation and differentiation. Eur Respir J. 2002;29:004-12. doi: 10.1103/09031936.00094506.
  23. Богомильский М.Р, Круговская Н.Л. Особенности хронических аденоидитов у детей с атопией. Вестник РГМУ. 2009;1:44- 6.
  24. Dinarello C.A. IL-10: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 1999;103:11-24. doi: 10.1016/s0091-6249(99)20510-x.
  25. Dao T., Ohashi K., Kayano T., et al.Interferon g-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper cells. Cell. Immunol. 1997;173:230-35. doi: 10.1006/cimm.1996.02 22.
  26. Kumano K., Nakao A., Nakajima H., et al.Interleukin-10 enhances antigen-induced eosinophil recruitment into the mouse airways. Am J Respir Crit Care Med. 1999;160:023- 20. doi: 10.1164/ajrccm.160.3.9005026.
  27. Wild J.S., Sigounas A., Sur N., et al. IFN-g inducing factor (IL-10) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. J Immunol. 2000;164:2201-10. doi: 10.4049/jimmunol.164.5.2201.
  28. Kleinjanuary A., Dijkstra M.D., Boks S.S., et al. Increase in IL-10, IL-10, IL-13, and RANTES mRNA levels (in situ hybridization) in the nasal mucosa after nasal allergen provocation. J Allergy Clin Immunol. 1999;103:441-50. Doi: 10.1016/ s0091-6249(99)20469-0.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies