Overview of laser and phototherapy techniques for the treatment of onychomycosis

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Abstract

Onychomycosis occurs in 10-20% of the population. Among all types of pathology of the nail apparatus, nail mycosis is the most common and accounts for at least 50%. This disease is not only considered an aesthetic defect, but also leads to severe systemic complications, so the study of this problem is extremely important in modern medicine. Unfortunately, the use of classical therapy in the form of local or systemic antifungal agents often does not lead to the desired result, entails a lot of adverse consequences (for example, in the form of toxic damage to the kidneys and liver when using itraconazole), recurrence of the infection. Therefore, it is necessary to look for alternative methods that will eliminate toxic drugs or at least reduce their dosage. This article discusses laser and phototherapy techniques for the treatment of onychomycosis, such as CO2 laser, photodynamic therapy, ultraviolet radiation, Nd:YAG laser.

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About the authors

S. I Surkichin

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Moscow, Russia

R. Yu Mayorov

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Moscow, Russia

M. I Arabadzhyan

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Moscow, Russia

References

  1. Цыкин А.А., Круглова Л.С., Курбатова И.В., Жукова О.В. К вопросу о профилактических мероприятиях при онихомикозах. Клиническая дерматология и венерология. 2014;5:54-8
  2. Gupta A.K., Versteeg S.G., Shear N.H. Confirmatory testing prior to initiating onychomycosis therapy is cost-effective. J Cutan Med Surg. 2018;22(2):129-41. doi: 10.1177/12034754 1 7733 461.
  3. Gupta A.K, Mays R.R., Versteeg S.G., et al. Update on current approaches to diagnosis and treatment of onychomycosis. Expert Rev AntiInfect Ther. 2018;16(12):929-38. doi: 10.1080/147872 1 0.2018.1544891.
  4. Сергеев Ю.Ю., Сергеев А.Ю. Oнихомикозы грибковые инфекции ногтей. М., 1998. 38 с.
  5. Клинические рекомендации: микозы кожи головы, туловища, кистей и стоп. Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов». 2020
  6. Bodman M.A., Krishnamurthy K. Onychomycosis. StatPearls [Internet]. aTreasure Island (FL): StatPearls Publishing. 2019 Jan.
  7. Gupta A.K., Sibbald R.G., Andriessen A., et al. Toenail onychomycosis - A Canadian approach with a new transungual treatment: Development of a clinical pathway. J Cutan Med Surg. 2015;19(5):440-49. doi: 10.1177/1203475415581310.
  8. Joyce A., Gupta A.K., Koenig L., et al. Fungal diversity and onychomycosis: An analysis of 8,816 toenail samples using quantitative PCR and next-generation sequencing. J Am Podiatr Med Assoc. 2019;109(1):57-63. doi: 10.7547/17-070.
  9. Thomas J., Jacobson G.A., Narkowicz C.K., et al. Toenail onychomycosis: An important global disease burden. J Clin Pharm Ther. 2010;35(5):497-519. doi: 10.1111/j.1365-2710.2009.01107.x.
  10. Youssef A.B., Kallel A., Azaiz Z., et al. Onychomycosis: Which fungal species are involved? Experience of the Laboratory of Parasitology-Mycology of the Rabta Hospital of Tunis. J Mycol Med. 2018;28(4):651-54. doi: 10.1016/j.mycmed.2018.07.005.
  11. Fike J.M., Kollipara R., Alkul S., Stetson C.L. Case report of onychomycosis and tinea corporis due to Microsporum gypseum. J Cutan Med Surg. 2018;22(1):94-6. doi: 10.1177/1203475417724439.
  12. Lipner S.R., Scher R.K. Onychomycosis: Clinical overview and diagnosis. JAm. Acad Dermatol. 2019;80(4):835-51. Doi: 10.1016/j. jaad.2018.03.062.
  13. Pang S.M., Pang J.Y.Y., Fook-Chong S., Tan A.L. Tinea unguium onychomycosis caused by dermatophytes: A ten-year (2005-2014) retrospective study in a tertiary hospital in Singapore. Singapore Med. J. 2018;59(10):524-doi: 10.11622/smedj.2018037.
  14. Sato T., Kitahara H., Honda H., et al. Onychomycosis of the middle finger of a Japanese judo athlete due to Trichophyton tonsurans. Med Mycol J. 2019;60(1):1-4. Doi: 10.3314/ mmj.18-00012.
  15. Sols-Arias M.P, Garca-Romero M.T. Onychomycosis in children. A review.Int J Dermatol. 2017;56(2):123-30. Doi: 10.1111/ ijd.13392.
  16. Bombace F., Iovene M.R., Galdiero M., et al. Non-dermatophytic onychomycosis diagnostic criteria: an unresolved question. Mycoses. 2016;59(9):558-65. Doi: 10.111 1/ myc.12504.
  17. Subramanya S.H., Subedi S., Metok Y., et al. Distal and lateral subungual onychomycosis of the finger nail in a neonate: A rare case. BMC Pediatr. 2019;19(1):168. doi: 10.1186/s12887-019-1549-9.
  18. Hoy N.Y, Leung A.K., Metelitsa A.I., Adams S. New concepts in median nail dystrophy, onychomycosis, and hand, foot, and mouth disease nail pathology. ISRN. Dermatol. 2012;2012:680163. doi: 10.5402/2012/680163.
  19. Elewski B.E, TostiA. Risk Factors and Comorbidities for Onychomycosis: Implications for Treatment with Topical Therapy. J Clin Aesthet Dermatol. 2015;8(11):38-42.
  20. Цыкин АА. Онихомикозы: ДНК-диагностика, совершенствование комбинированной терапии. Дисс. канд. мед. наук. М., 2008.
  21. Хмельницкий О.К., Хмельницкая Н.М. Патоморфология микозов человека. СПб., 2005. 432 с.
  22. Скрипкин Ю.К., Бутов Ю.С. Клиническая дерматовенерология в 2-х т. М., 2009. Т. I. 720 с.
  23. Сергеев А.Ю., Сергеев Ю.В. Грибковые инфекции. Руководство для врачей. 2-е изд. М., 2008. 480 с.
  24. Elewski B.E. Onychomycosis: Pathogenesis, Diagnosis, and Management. Clin. Microbiol. 1998;11:415-29.
  25. Карпова О.А. Взаимосвязь течения онихоми-коза стоп и изменений нейрофункциональ-ных и нейровизуализационных показателей у железнодорожников. Дисс. канд. мед. наук. Н., 2007.
  26. Потекаев Н.Н., Потекаев Н.С. Современные представления об этиологии, патогенезе, клиники и терапии онихомикоза. Consilium medicum. 2001;3-5.
  27. Brooks C., Kujawska A., Patel D. Cutaneous allergic reactions induced by 20 sporting activities. Sports Med. 2003;33(9):699-708. Doi: 10.2 1 65/0000 72 56-2 00333 090-00005.
  28. Leung A.K.C., Lam J.M., Leong K.F., et al. Onychomycosis: An Updated Review. Recent Pat Inflamm Allergy Drug Discov. 2020;14(1):32-45. doi: 10.2174/1872213X1366619102609 0713.
  29. Baran R., Sigurgeirsson B., de Berker D., et al. A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement. Br J Dermatol. 2007;157:149-57. doi: 10.1111/j.1365-2133.2007.07974.x.
  30. Потекаев Н.Н., Круглова Л.С. Лазер в дерматологии и косметологии. М., 2018. 280 с.
  31. Ranjan E., Arora S., Sharma N. Fractional CO2 laser with topical 1% terbinafine cream versus oral itraconazole in the management of onychomycosis: A randomized controlled trial. Indian J Dermatol Venereol Leprol. 2022 Mar 24:1-7. doi: 10.25259/IJDVL_98_2021.
  32. Kandpal R., Arora S., Arora D. A Study of Q-switched Nd:YAG Laser versus Itraconazole in Management of Onychomycosis. J Cutan Aesthet Surg. 2021;14(1):93-100. doi: 10.4103/JCAS. JCAS_29_20.
  33. Ma W., Si C., Kasyanju Carrero L.M., et al. Laser treatment for onychomycosis: A systematic review and meta-analysis. Medicine (Baltimore). 2019;98(48):e17948. Doi: 10.1097/ MD.0000000000017948.
  34. Nematollahi A.R., Badiee P., Nournia E. The Efficacy of Ultraviolet Irradiation on Trichophyton Species Isolated From Nails. Jundishapur J Microbiol. 2015;8(6):e18158. doi: 10.5812/jjm.18158v2.
  35. Круглова Л.С., Котенко К.В., Корчажкина Н.Б., Турбовская С.Н. Физиотерапия в дерматологии. М., 2016. 304 с.
  36. Sacks D., Baxter B., Campbell B.C.V., et al. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke.Int J Stroke. 2018;13(6):612-32. doi: 10.1177/1747493018778713.
  37. Круглова Л.С., Суркичин С.И., Грязева Н.В., Холупова Л.С. Фотодинамическая терапия. 2020. 135 с.

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