Rationale for the use of trospium chloride in the first line of therapy for overactive bladder
- Authors: Danilov V.V.1,2, Volnykh I.Y.1
-
Affiliations:
- Pacific State Medical University
- Far Eastern Federal University
- Issue: Vol 30, No 1/2 (2023)
- Pages: 226-230
- Section: Urology/nephrology
- URL: https://journals.eco-vector.com/2073-4034/article/view/463138
- DOI: https://doi.org/10.18565/pharmateca.2023.1-2.226-230
- ID: 463138
Cite item
Open Access
Access granted
Abstract
The problem of an overactive bladder has been relevant for the last decades. Currently, drugs from the pharmacological group of M-cholinolytics, which increase the functional capacity of the bladder and reduce the severity of the clinical picture of urination disorders, are considered to be the main tool for the treatment. Moreover, M-anticholinergics with the chemical structure of tertiary amines affect the central nervous system. In this regard, trospium chloride, being a water-soluble quaternary base, has significant advantages in diagnosing the functional state of the central nervous system while prescribing treatment.
Full Text
About the authors
Vadim V. Danilov
Pacific State Medical University; Far Eastern Federal University
Author for correspondence.
Email: Vadim_danilov@list.ru
Dr. Sci. (Med.), Urologist, Professor at the Institute of Surgery, Department of Clinical Pharmacology
Russian Federation, Vladivostok; VladivostokI. Yu. Volnykh
Pacific State Medical University
Email: Vadim_danilov@list.ru
Institute of Surgery
Russian Federation, VladivostokReferences
- Abrams P., et al. The Standartisation of Terminology of Lower Urinary Tract Function: Report from the Standartisation Sub-comittee of International Continence Society. Neurourol Urodyn. 2002;21:167–78. doi: 10.1002/nau.10052.
- Chen G., Lin T., Hu S., Chen Y., Lin L. Prevalence and Correlation of Urinary Incontinence and Overactive Bladder in Taiwanese Women. Neurourol Urodyn. 2003;22(2):109–17. Doi: 10.1002/ nau.10010.
- Cardozo L., et al. Efficacy of trospium chloride in patients with detrusor instability; placebo controlled, randomized, double-blind, multicenter clinical trial. BJU Int. 2000;85:659–64. doi: 10.1046/j.1464-410x.2000.00575.x.
- Данилов В.В., Данилов В.В., Данилов В.В. Синдром гиперактивного мочевого пузыря и женские сексуальные дисфункции. Справочник поликлинического врача. 2018;2:53–7. [Danilov V.V., Danilov V.V., Danilov V.V. Overactive bladder syndrome and female sexual dysfunction. Spravochnik poliklinicheskogo vracha. 2018;2:53–7. (In Russ.)].
- Данилов В.В., Лоран О.Б. Диагностика и лечение стрессовой и смешанной форм недержания мочи у женщин. Океанские Вести. 2012. 223 с. [Danilov V.V., Laurent O.B. Diagnosis and treatment of stress and mixed forms of urinary incontinence in women. Ocean News. 2012. 223 p. (In Russ.)].
- Petzinger E., Gavrilova O., Geyer J., Schwantes U. The role of the MDR1 transporter in body distribution and brain penetration of the trospium chloride and oxybutynin. Eur Urol Suppl. 2008;7(3):675. doi: 10.1016/s1569-9056(08)60673-9.
- Данилов В.В., Данилова Т.И., Данилов В.В. Клинико-уродинамическое подтверждение нейрофизиологической модели гиперактивного мочевого пузыря. Урология. 2010;4:15–20. [Danilov V.V., Danilova T.I., Danilov V.V. Clinical and urodynamic confirmation of the neurophysiological model of an overactive bladder. Urologia=Urology. 2010;4:15–20. (In Russ.)].
- Данилов В.В., Данилов В.В. Нейроурология. T. 1. Владивосток, 2019. 280 с. [Danilov V.V., Danilov V.V. Neurourology. T. 1. Vladivostok, 2019. 280 p. (In Russ.)].
Supplementary files
