Evaluation of long-term results of treatment of patients with residual tumors (including those with minimal forms of ypT1abN0), with pathomorphological complete response (pCR) after neoadjuvant systemic therapy, with primary minimal breast cancer (pT1abN0M0)

Roman S. Pesotsky; Песоцкий Роман Сергеевич; V. F. Semiglazov; Семиглазов В. Ф.; P. V. Krivorotko; Криворотько П. В.; T. T. Tabagua; Табагуа Т. Т.; K. Yu. Zernov; Зернов К. Ю.; A. S. Emelyanov; Емельянов А. С.; T. Yu. Semiglazova; Семиглазова Т. Ю.; N. Amirov; Амиров Н.; V. V. Mortada; Мортада В. В.; D. G. Ulrikh; Ульрих Д. Г.; V. E. Levchenko; Левченко В. Е.; K. Yu. Rychagov; Рычагов К. Ю.; K. Y. Zirov; Зиров К. Ю.; V. N. Evseev; Евсеев В. Н.

doi:10.18565/pharmateca.2023.6-7.59-67

Evaluation of long-term results of treatment of patients with residual tumors (including those with minimal forms of ypT1abN0), with pathomorphological complete response (pCR) after neoadjuvant systemic therapy, with primary minimal breast cancer (pT1abN0M0)

作者: Pesotsky R.S.¹, Semiglazov V.F.¹^,2, Krivorotko P.V.¹, Tabagua T.T.¹, Zernov K.Y.¹, Emelyanov A.S.¹, Semiglazova T.Y.¹, Amirov N.¹, Mortada V.V.¹, Ulrikh D.G.¹, Levchenko V.E.³, Rychagov K.Y.¹, Zirov K.Y.⁴, Evseev V.N.⁵
隶属关系:
1. N.N. Petrov National Medical Research Center of Oncology
2. North-Western State Medical University n.a. I.I. Mechnikov
3. City Clinical Oncological Dispensary
4. Russian Biotechnological University (ROSBIOTECH)
5. LLC MEDSI
期: 卷 30, 编号 6/7 (2023)
页面: 59-67
栏目: Original articles
URL: https://journals.eco-vector.com/2073-4034/article/view/562797
DOI: https://doi.org/10.18565/pharmateca.2023.6-7.59-67
ID: 562797

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Background. Initially, minimal tumors are characterized by high survival rates, which are proved by international and domestic studies. It is required to clarify the survival rates in the presence of a minimal residual tumor (ypT <10mm) after neoadjuvant systemic therapy in patients with breast cancer (BC) and to compare with primary minimal forms of BC (pT1a-b N0M0), characterized by the most favorable prognosis.

Objective. Improvement of the effectiveness of treatment of residual minimal forms (ypT1a-b) of BC after NST.

Methods. The study included 602 patients aged 18–65 years with early and locally advanced I–IIIC stage T1-3N1-3M0 breast cancer, who underwent complex or combined treatment. This study included patients treated at the N.N. Petrov National Medical Research Center of Oncology from 2015 to 2021.

Results and discussion. Our data analysis revealed that the survival rates (DFS and OS) of patients with minimal residual tumor after neojuvant systemic therapy were not comparable with those in the group of patients with primary minimal breast cancer.

Conclusion. After reaching a complete pathomorphological response of the tumor to NST (RCB 0), the 5-year disease-free (DFS) and overall (OS) survival rates (DFS – 78.5%; OS – 90.4%) were inferior to the survival rates of patients with primary minimal breast cancer (pT1ab N0M0) [DFS – 86.4%; OS – 98.6%].

关键词

breast cancer, minimal cancer, neoadjuvant systemic therapy, chemotherapy, complete pathomorphological regression

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作者简介

Roman Pesotsky

N.N. Petrov National Medical Research Center of Oncology

编辑信件的主要联系方式.
Email: shipmeback@gmail.com
ORCID iD: 0000-0002-2573-2211

Oncologist, Department of Breast Tumors

俄罗斯联邦, St. Petersburg

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