The role of systemic enzyme therapy with phlogenzym in the prevention of postoperative complications in gynecological practice

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Abstract

Surgical treatment in gynecological practice is characterized by a relatively high incidence of postoperative complications, including pain, inflammation, infections, adhesions, etc. Systemic oral enzyme therapy can contribute to the prevention of complications and their effective relief. The drug Flogenzym has the necessary anti-inflammatory, analgesic and antiplatelet effects due to the complex action of its components, successfully prevents and reduces the intensity of possible negative consequences of surgical treatment.

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About the authors

Inna A. Apolikhina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology; Sechenov University

Author for correspondence.
Email: i_apolikhina@oparina4.ru
ORCID iD: 0000-0002-4581-6295

Dr. Sci. (Med.), Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation; Professor at the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Postgraduate Education

Russian Federation, Moscow; Moscow

References

  1. Weiser T.G., Haynes A.B., Molina G., et al. Size and distribution of the global volume of surgery in 2012. Bull World Health Organ. 2016;94(3):201–9. doi: 10.2471/BLT.15.159293.
  2. Tevis S.E., Cobian A.G., Truong H.P., et al. Implications of multiple complications on the postoperative recovery of general surgery patients. Ann Surg. 2016;263(6):1213–18. doi: 10.1097/SLA.0000000000001390.
  3. Erekson E.A., Yip S.O., Ciarleglio M.M., Fried T.R. Postoperative complications after gynecologic surgery. Obstet Gynecol. 2011 Oct;118(4):785–93. doi: 10.1097/AOG.0b013e31822dac5d.
  4. Bahadur A., Mundhra R., Kashibhatla J., et alS. Intraoperative and Postoperative Complications in Gynaecological Surgery: A Retrospective Analysis. Cureus. 2021;13(5):e14885. doi: 10.7759/cureus.14885.
  5. Stany M.P., Farley J.H. Complications of gynecologic surgery. Surg Clin North Am. 2008;88(2):343–59. doi: 10.1016/j.suc.2007.12.004.
  6. Dobrokhotova Yu.E., Ter-Ovanesov M.D., Borovkova E.I. et al. The concept of accelerated recovery after operations in oncogynecology. Russkii meditsinskii zhurnal. Mat’ i ditya. 2018;26(5(I)):45–50. (In Russ.).
  7. Targoni O., Lehmann P.V. Modulation of the activation threshold for autoreactive T cells via systemic enzyme therapy with phlogenzym®. J Neuroimmunol. 1995;56:66. doi: 10.1016/0165-5728(95)99091-V.
  8. Wald M., Honzikova M., Lysikova M. Systemic enzyme support: an overview. Nutr News. 2008;4:2–5.
  9. Julovi S.M., Xue M., Dervish S., et al. Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38. The Am J Pathol. 2011;179(5):2233–42.
  10. Fitzhugh D.J., Shan S., Dewhirst M.W., Hale L.P. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clin Immunol. 2008;128(1):66–74.
  11. Walad M., Honzikova M., Lysikova M. Systemic enzyme support: an overview. Nutr. News. 2008;4:2–5.
  12. Targoni O., Lehmann P.V. Modulation of the activation threshold for autoreactive T cells via systemic enzyme therapy with phlogenzym®. J. Neuroimmunol. 1995;56:66. doi: 10.1016/0165-5728(95)99091-V.
  13. Julovi S.M., Xue M., Dervish S., et al. Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38. Am. J. Pathol. 2011;179(5):2233–42. doi: 10.1016/j.ajpath.2011.07.024.
  14. Fitzhugh D.J., Shan S., Dewhirst M.W., Hale L.P. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clin Immunol. 2008;128(1):66–74. doi: 10.1016/j.clim.2008.02.015.
  15. Pereira I.C., et al. Bromelain supplementation and inflammatory markers: a systematic review of clinical trials. Clin Nutrit ESPEN. 2023;55:116–27. doi: 10.1016/j.clnesp.2023.02.028
  16. Muller S., Marz R., Schmolz M., et al. Placebo-controlled randomized clinical trial on the immunomodulating activities of low-and high-dose bromelain after oral administration-new evidence on the antiinflammatory mode of action of bromelain. Phytother. Res. 2013;27(2):199–204. doi: 10.1002/ptr.4678.
  17. Maurer H.R. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58(9):1234–45. doi: 10.1007/PL00000936.
  18. Ganeshpurkar A., Saluja A.K. The pharmacological potential of rutin. Saudi Pharma J. 2017;25(2):149–64. doi: 10.1016/j.jsps.2016.04.025.
  19. Sheu J.R., Hsiao G., Chou P.H., et al. Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. J Agric Food Chem. 2004;52(14):4414–18. doi: 10.1021/jf040059f.
  20. Giannini A., Palla G., Goglia L., et al. Effects of preoperative and perioperative administration of wobenzym vital on minimal-mild endometriosis. J Endometr. 2015;7(2):71–7. doi: 10.5301/je.5000215.
  21. Mirzabalaeva A.K., Klimko N.N., Yarobkova N.D. Wobenzym* in complex therapy of actinomycosis of abdominal cavity and small pelvis in women. Probl Med Mykol. 1999;1(1):45–50.
  22. Srivastava S.P., Agarwal S.P. Role of enzyme-flavonoid therapy in controlling inflammatory pathology of pelvic inflammatory disease. Indian J Obstet Gynecol Res. 2022;9(3):317–22.
  23. Mitrokhin S.D., Sternin Yu.I. The importance of immunobiological preparations in the prevention of surgical site infections in cancer patients. Effektivnaya farmakoterapiya. Onkologiya, gematologiya i radiologiya=Oncol Hematol Radiol. 2011;4:46–52. (In Russ.).
  24. Lazarenko V.A., Konoplya A.I., Lipatov V.A., et al. To the question of role of the immune system in the development of the adhesion process of abdominal cavity (literature review). Innova. 2016;(4):29–33. (In Russ.).
  25. Sulima A.N., Davydova A.A., Rybalka A.N. Features of the prevention and treatment of adhesions in patients with chronic inflammatory diseases of the pelvic organs. Ginekologiya=Gynecology. 2018;20(1):62–7. (In Russ.).
  26. Tikhomirov A.L., Manukhin I.B., Kazenashev V.V. et al. Prevention of adhesions and its complications in operative gynecology. Rossiiskii vestnik akushera-ginekologa. 2016;16(5):100–5. (In Russ.).
  27. Chekmazov I.A. Adhesive disease of the abdominal cavity pathogenesis, clinic, diagnosis, treatment and prevention). Diss. Doct. of Med. Sciences. Moscow, 2004. (In Russ.).
  28. Lineva O.I., Shatunova E.P., Kaganova M.A. Pathological and immunological aspects of chronic salpingoophoritis and ways of correction. Russkii meditsinskii zhurnal. 2006;14(18):1301–3. (In Russ.).
  29. Adamyan L.V., Kozachenko A.V., Kondratovich L.M. Peritoneal adhesions: the history of researh, classification and pathogenesis (a review). Problemy reproduktsii=Rus J Hum Reprod. 2013;(6):7–13. (In Russ.).
  30. Saed G.M., Diamond M.P. Molecular characterization of postoperative adhesions: the adhesion phenotype. J Am Assoc Gynecol Laparosc. 2004;11:307–14. doi: 10.1016/s1074-3804(05)60041-2.
  31. Samartsev V.A., Gavri-lov V.A., Pushkarev B.S., et al. Adhesive disease: state of the problem and modern methods of prevention. Problemy reproduktsii=Perm Med J. 2019;36(3):72–90. (In Russ.).
  32. Minaev S.V., Obozin V.S., Barnash G., Obedin A.N. The influence of enzymes on adhesive process in abdominal cavity. Eur J Pediatr Surg. 2009;19(6):380–83. doi: 10.1055/s-0029-1241847.
  33. Trunin E.M, Kandalova I.G. The role of systemic enzyme therapy in the prevention of postoperative complications in surgical treatment of diffuse toxic goite. Prakticheskaya meditsina. 2012;3:122–25. (In Russ.).
  34. Shatunova E.P., Lineva O.I., Kaganova M.A. Immune profile and optimization of treatment of patients with chronic salpingo-oophoritis. Rossiiskii vestnik akushera-ginekologa. 2016;6:83. (In Russ.).
  35. Belskikh O.L., Korotkikh I.N. Systemic enzyme therapy in the treatment of abdominal adhesions after reconstructive plastic surgery on the fallopian tubes. Akusherstvo i ginekologiya=Obstetr Gynecol. 2019;12:184–86. (In Russ.).
  36. Burlev V.A. Pelvic peritoneum and peritoneal adhesions: inflammatory stress. Problemy reproduktologii. 2015;1:15–25. (In Russ.).

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