Sulodexide: meta-analysis of the treatment of diabetic nephropathy and literature review

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Objective. Discussion of the results of a meta-analysis that was conducted to evaluate the effectiveness of sulodexide treatment of diabetic nephropathy.

Results. Sulodexide is a heterogeneous group of sulfated glycosaminoglycans; which mainly consists of low molecular weight heparin. Clinical studies have shown that sulodexide is able to reduce urinary albumin excretion in patients with type 1 and type 2 diabetes mellitus (DM). A meta-analysis was conducted to summarize the clinical results of all prospective clinical studies on the clinical efficacy and safety of sulodexide in diabetic patients with nephropathy. In general; sulodexide therapy was accompanied by a significant decrease in urinary protein excretion. In the sulodexide group; 220 patients (17.7%) achieved a reduction in albumin excretion of at least 50% compared with 141 (11.5%) in the placebo group. The odds ratio in patients with therapeutic efficacy between the sulodexide and placebo groups was 3.28 (95% confidence interval: 1.34–8.06; P=0.01).

Conclusion. These data indicate the renoprotective effect of sulodexide in diabetic patients with microand macroalbuminuria and may be the basis for the treatment of diabetic nephropathy with sulodexide; in particular; the prevention of end-stage renal disease associated with DM [1].

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作者简介

Maria Novikova

Endocrinological Dispensary of the Moscow Healthcare Department; Central State Medical Academy of the Administrative Department of the President of the Russian Federation

编辑信件的主要联系方式.
Email: citrus7474@mail.ru
ORCID iD: 0000-0003-1320-0565

Cand. Sci. (Med.), Associate Professor at the Department of Therapy; Cardiology and Functional Diagnostics with a Course in Nephrology, Nephrologist

俄罗斯联邦, Moscow; Moscow

O. Koteshkova

Endocrinological Dispensary of the Moscow Healthcare Department

Email: citrus7474@mail.ru
俄罗斯联邦, Moscow

M. Antsiferov

Endocrinological Dispensary of the Moscow Healthcare Department

Email: citrus7474@mail.ru
俄罗斯联邦, Moscow

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2. Fig. 1. Flow chart of study selection

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3. Fig. 2. Antiproteinuric effect of sulodexide assessed by AER reduction in eight studies

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4. Fig. 3. Antiproteinuric effect of sulodexide assessed by the proportion of patients achieving a therapeutic effect in six studies

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5. Fig. 4. Results of changes in serum creatinine in three studies

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6. Fig. 5. Funnel plots of sulodexide treatment efficacy

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