Disturbances of the gut microbiota and their correction in patients with oxalate nephrolithiasis

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Abstract

The complex of microorganisms found in the intestine (gut microbiota) influences the pathogenesis of a number of diseases. There are theories that gastrointestinal diseases increase the risk of development and recurrence of urolithiasis. Current evidence presented in this article demonstrates a link between gut microbiota, particularly Oxalobacter formigenes, and the formation of oxalate kidney stones. The connection between inflammatory bowel diseases and the use of antimicrobial drugs with oxalate homeostasis is shown, and ways of correcting the gut microbiota in patients with urolithiasis using diet therapy, probiotics, and fecal microbiota transplantation are analyzed. The article presents research results demonstrating that correction of the gut microbiota can be a therapeutic goal and may become an important component of the complex treatment of nephrolithiasis.

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About the authors

N. V. Sturov

Medical Institute, RUDN University

Email: zakhar.ivanov@list.ru
ORCID iD: 0000-0002-3138-8410

Department of General Medical Practice

Russian Federation, Moscow

S. V. Popov

Medical Institute, RUDN University

Email: zakhar.ivanov@list.ru
ORCID iD: 0000-0002-0567-4616

Department of General Medical Practice

Russian Federation, Moscow

Zakhar A. Ivanov

Medical Institute, RUDN University

Author for correspondence.
Email: zakhar.ivanov@list.ru
ORCID iD: 0000-0002-6655-0369

teaching assistant at the Department of General Medical Practice

Russian Federation, Moscow

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