A case of pseudoxanthoma elasticus in a young woman
- Authors: Novikov A.I.1, Novikov Y.A.1, Zubareva E.Y.1, Okhlopkov V.A.2
-
Affiliations:
- Omsk State Medical University
- Federal Scientific and Clinical Center for Resuscitation and Rehabilitation
- Issue: Vol 31, No 1 (2024)
- Pages: 188-191
- Section: Dermatology/allergology
- URL: https://journals.eco-vector.com/2073-4034/article/view/632310
- DOI: https://doi.org/10.18565/pharmateca.2024.1.188-191
- ID: 632310
Cite item
Abstract
Background. A case of clinical observation of a 32-year-old patient with pseudoxanthoma elasticus (PXE) in the skin folds is presented. A rare genetically determined dermatosis is characterized by progressive calcification and fragmentation of elastic fibers in various tissues, including the skin (especially in the folds), eyes (angioid streaks and retinal defects) and the cardiovascular system (arterial hypertension, gastrointestinal bleeding and vascular damage).
Description of a clinical case. The clinical picture on the skin developed in childhood. Gradually, typical yellowish papules appeared, with a symmetrical location in the neck and armpits; due to asymptomatic nature, the patient did not notice their presence until adolescence. The pathological process progresses, typical papules appear in the groin areas, the elements are grouped, and the elasticity of the skin decreases. The diagnosis was made based on the clinical picture and histological description of a neck skin biopsy. Consultation with an ophthalmologist is recommended. Angioid streaks on the fundus are not specific for PXE, but often provide significant assistance in identifying the disease: they can precede skin changes or be isolated lesions.
Conclusion. Clinical observation of this case is of interest to practicing dermatologists and cosmetologists.
Full Text
![Restricted Access](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
About the authors
A. I. Novikov
Omsk State Medical University
Email: elenazubareva@mail.ru
ORCID iD: 0000-0002-3764-9239
SPIN-code: 3715-1010
Russian Federation, Omsk
Yu. A. Novikov
Omsk State Medical University
Email: elenazubareva@mail.ru
ORCID iD: 0000-0003-0391-5372
SPIN-code: 2709-3818
Russian Federation, Omsk
Elena Yu. Zubareva
Omsk State Medical University
Author for correspondence.
Email: elenazubareva@mail.ru
ORCID iD: 0000-0003-1156-682X
SPIN-code: 6707-9929
Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology
Russian Federation, OmskV. A. Okhlopkov
Federal Scientific and Clinical Center for Resuscitation and Rehabilitation
Email: elenazubareva@mail.ru
ORCID iD: 0000-0003-0688-6925
SPIN-code: 1202-6653
Russian Federation, Moscow
References
- Хегер П.Г. Детская дерматология. Дифференциальная диагностика и лечение у детей и подростков. Пер. с нем. В.П. Адаскевича, под ред. Кубановой А.А., Львова А.Н. М., 2013. [Heger P.G. Pediatric dermatology. Differential diagnosis and treatment in children and adolescents. Translation from German by V.P. Adaskevich, ed. by Kubanova A.A., Lvov A.N. Moscow, 2013. (In Russ.)].
- Скрипкин Ю.К., Мордовцев В.Н. Руководство для врачей. Т. 2. М., 1999. [Skripkin Yu.K., Mordovtsev V.N. Guide for doctors. Vol. 2. Moscow, 1999. (In Russ.)].
- Мурашкин Н.Н., Пильгуй Э.И. Эластическая псевдоксантома в детском возрасте. Вопросы современной педиатрии. 2016;6;635–39. [Murashkin N.N., Pilguy E.I. Elastic pseudoxanthoma in childhood. Voprosy sovremennoi pediatrii. 2016;6:635–39. (In Russ.)].
- Вольф К., Голдсмит Лоуэлл А., Стивен И. Кац и др. Дерматология Фицпатрика в клинической практике. Пер. с англ.; под общ. ред. акад. А.А. Кубановой. М., 2012. Т. 2. [Wolf K., Goldsmith Lowell A., Steven I Katz, et al. Fitzpatrick’s Dermatology in Clinical Practice. Translation from English; under the general editorship of Academician A.A. Kubanova. Moscow, 2012. Vol. 2. (In Russ.)].
- Marconi B., Bobyr I., Campanati A., et al. Pseudoxanthoma elasticum and skin: Clinical manifestations, histopathology, pathomechanism, perspectives of treatment. Intractable Rare Dis Res. 2015;4(3):113–22.
- Фицпатрик Т., Джонсон Р., Вулф К., Полано М., Сюрмонд Д. Дерматология. Атлас-справочник. Пер. с англ. И.В. Журавлева. М. 1998. [Fitzpatrick T., Johnson R., Wolfe K., Polano M., Surmond D. Dermatology. Atlas-directory. Translation from English by I.V. Zhuravlev. Moscow, 1998. (In Russ.)].
Supplementary files
![](/img/style/loading.gif)