Molecular biological transformation of the pelvic floor during pregnancy and the postpartum period (literature review)

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Abstract

An analysis of literature data on epidemiology, morphofunctional changes and molecular mechanisms of remodeling of the connective tissue of the woman’s reproductive system during pregnancy, childbirth and the postpartum period was carried out. The search and analysis of publications in the PUBMED, ScienceDirect, eLIBRARY.RU databases was carried out. The importance of genes that control the processes of synthesis and degradation of connective tissue, in particular the genes for collagen, fibulin and lysyl oxidase-like protein, is described. The place of matrix metalloproteinases and their tissue inhibitors in the proteolytic degradation of the extracellular matrix of connective tissue is discussed. Modern data on methods for assessing the function and strength of the pelvic floor muscles in women during pregnancy are presented, and modern possibilities for conservative treatment of women with pelvic floor dysfunction namely, the use of high-frequency radiotherapy with a detailed description of the mechanisms of effectiveness, are revealed.

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About the authors

Anastasia L. Varlamova

Ural Research Institute for Maternity and Infancy Protection

Author for correspondence.
Email: anastasiia.var@yandex.ru
ORCID iD: 0009-0008-7703-4248

PhD student, Obstetrician-Gynecologist

Russian Federation, Ekaterinburg

A. A. Mikhelson

Ural Research Institute for Maternity and Infancy Protection

Email: anastasiia.var@yandex.ru
ORCID iD: 0000-0003-1709-6187
Russian Federation, Ekaterinburg

Yu. A. Semenov

Ural Research Institute for Maternity and Infancy Protection

Email: anastasiia.var@yandex.ru
ORCID iD: 0000-0002-4109-714X
Russian Federation, Ekaterinburg

O. A. Melkozerova

Ural Research Institute for Maternity and Infancy Protection

Email: anastasiia.var@yandex.ru
ORCID iD: 0000-0002-4090-0578
Russian Federation, Ekaterinburg

M. V. Lazukina

Ural Research Institute for Maternity and Infancy Protection

Email: anastasiia.var@yandex.ru
ORCID iD: 0000-0002-0525-0856
Russian Federation, Ekaterinburg

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