A clinical case of early coronary atherosclerosis complicated by acute myocardial infarction in a young man with unspecified familial hypercholesterolemia

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详细

Familial hypercholesterolemia (FH) is a hereditary autosomal dominant disorder characterized by elevated low-density lipoprotein (LDL) levels and decreased numbers of functioning receptors for them. A serious complication of FH is systemic atherosclerosis, which occurs in young people, and even children, who do not have risk factors for cardiovascular diseases (CVD). Untimely diagnosis, lack of specific treatment can lead to the development of premature acute myocardial infarction (AMI) and stroke, early cardiovascular death or disability of patients. The authors present a description of a case of early coronary atherosclerosis complicated by AMI in a young man 37 years old with unspecified FH.

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作者简介

Larisa Tarasova

I.N. Ulyanov Chuvash State University; Republican Clinical Hospital; Institute for Advanced Medical Education

编辑信件的主要联系方式.
Email: tlarisagast18@mail.ru
ORCID iD: 0000-0003-1496-0689

Dr. Sci. (Med.), Associate Professor, Head of the Department of Faculty and Hospital Therapy, Professor at the Department of Public Health and Healthcare, Head of the Gastroenterology Department

俄罗斯联邦, Cheboksary; Cheboksary; Cheboksary

Liana Porfiryeva

I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary

Email: krasnova-liana@mail.ru
ORCID iD: 0009-0009-0256-9704

post-graduate student, Department of Faculty and Hospital Therapy, Cardiologist at the Cardiology Department No. 4

俄罗斯联邦, Cheboksary; Cheboksary

Olga Dimitrieva

I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary

Email: salgarii@mail.ru
ORCID iD: 0000-0002-7771-6141

Cand. Sci. (Med.), Associate Professor of the Department of Hospital Therapy, Cardiologist

俄罗斯联邦, Cheboksary; Cheboksary

Nadezhda Kucherova

I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary

Email: nadezda_kan@mail.ru
ORCID iD: 0000-0002-9500-3719

post-graduate student, Department of Faculty and Hospital Therapy, Cardiologist

俄罗斯联邦, Cheboksary; Cheboksary

参考

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  6. Yang J., Biery D.W., Singh A., et al. Risk factors and outcomes of very young adults who experience myocardial infarction: the partners YOUNG-MI Registry. Am J Med. 2020;133(5):605–612.e1. doi: 10.1016/j.amjmed.2019.10.020.
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  8. Yao H., Farnier M., Tribouillard L., et al. Coronary lesion complexity in patients with heterozygous familial hypercholesterolemia hospitalized for acute myocardial infarction: data from the RICO survey. Lipids Health Dis. 2021;20(1):45. doi: 10.1186/s12944-021-01467-z.
  9. McGowan M.P., Hosseini Dehkordi S.H., et al. Diagnosis and treatment of heterozygous familial hypercholesterolemia. J Am Heart Assoc. 2019;8(24):e013225. doi: 10.1161/JAHA.119.013225.
  10. Ложкина Н.Г., Спиридонов А.Н. Клинический случай инфаркта миокарда с неуточненной формой семейной гиперхолестеринемии. Атеросклероз. 2021;17(4):74–78. [Lozhkina N.G., Spiridonov A.N. Clinical case of myocardial infarction with unspecified familial hypercholesterolemia. Ateroscleroz. 2021;17(4):74–78. (In Russ.)]. doi: 10.52727/2078-256X-2021-17-4-74-78.

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2. Fig. Angiogram of the coronary arteries of patient M. PBV (subtotal stenosis (arrow), with a partially washed filling defect in the lumen, distal blood flow TIMI1-11)

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