A clinical case of early coronary atherosclerosis complicated by acute myocardial infarction in a young man with unspecified familial hypercholesterolemia
- 作者: Tarasova L.V.1,2,3, Porfiryeva L.A.1,4, Dimitrieva O.V.1,4, Kucherova N.Y.1,4
-
隶属关系:
- I.N. Ulyanov Chuvash State University
- Republican Clinical Hospital
- Institute for Advanced Medical Education
- Republican Cardiology Dispensary
- 期: 卷 32, 编号 1 (2025)
- 页面: 71-75
- 栏目: Cardiology
- URL: https://journals.eco-vector.com/2073-4034/article/view/679937
- DOI: https://doi.org/10.18565/pharmateca.2025.1.71-75
- ID: 679937
如何引用文章
详细
Familial hypercholesterolemia (FH) is a hereditary autosomal dominant disorder characterized by elevated low-density lipoprotein (LDL) levels and decreased numbers of functioning receptors for them. A serious complication of FH is systemic atherosclerosis, which occurs in young people, and even children, who do not have risk factors for cardiovascular diseases (CVD). Untimely diagnosis, lack of specific treatment can lead to the development of premature acute myocardial infarction (AMI) and stroke, early cardiovascular death or disability of patients. The authors present a description of a case of early coronary atherosclerosis complicated by AMI in a young man 37 years old with unspecified FH.
全文:

作者简介
Larisa Tarasova
I.N. Ulyanov Chuvash State University; Republican Clinical Hospital; Institute for Advanced Medical Education
编辑信件的主要联系方式.
Email: tlarisagast18@mail.ru
ORCID iD: 0000-0003-1496-0689
Dr. Sci. (Med.), Associate Professor, Head of the Department of Faculty and Hospital Therapy, Professor at the Department of Public Health and Healthcare, Head of the Gastroenterology Department
俄罗斯联邦, Cheboksary; Cheboksary; CheboksaryLiana Porfiryeva
I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary
Email: krasnova-liana@mail.ru
ORCID iD: 0009-0009-0256-9704
post-graduate student, Department of Faculty and Hospital Therapy, Cardiologist at the Cardiology Department No. 4
俄罗斯联邦, Cheboksary; CheboksaryOlga Dimitrieva
I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary
Email: salgarii@mail.ru
ORCID iD: 0000-0002-7771-6141
Cand. Sci. (Med.), Associate Professor of the Department of Hospital Therapy, Cardiologist
俄罗斯联邦, Cheboksary; CheboksaryNadezhda Kucherova
I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary
Email: nadezda_kan@mail.ru
ORCID iD: 0000-0002-9500-3719
post-graduate student, Department of Faculty and Hospital Therapy, Cardiologist
俄罗斯联邦, Cheboksary; Cheboksary参考
- Ежов М.В., Бажан С.С., Ершова А.И., и др. Клинические рекомендации по семейной гиперхолестеринемии. Атеросклероз. 2019;15(1):58–98. [Ezhov M.V., Bazhan S.S., Ershova A.I., et al. Clinical guidelines for familial hypercholesterolemia. Atherosclerosis. 2019;15(1):58–98. (In Russ.)].
- Tokgozoglu L., Kayikcioglu M. Familial Hypercholesterolemia: global burden and approaches. Curr Cardiol Rep. 2021;23(10):151. doi: 10.1007/s11886-021-01565-5.
- Sawhney J.P.S., Madan K. Familial hypercholesterolemia. Indian Heart J. 2024;76(S1):S108–S112. doi: 10.1016/j.ihj.2023.12.002.
- Berta E., Zsiros N., Bodor M., et al. Clinical aspects of genetic and non-genetic cardiovascular risk factors in familial hypercholesterolemia. Genes (Basel). 2022;13(7):1158. doi: 10.3390/genes13071158.
- de Oliveira J., Moreira E.L.G., de Bem AF. Beyond cardiovascular risk: implications of familial hypercholesterolemia on cognition and brain function. Ageing Res Rev. 2024;93:102149. doi: 10.1016/j.arr.2023.102149.
- Yang J., Biery D.W., Singh A., et al. Risk factors and outcomes of very young adults who experience myocardial infarction: the partners YOUNG-MI Registry. Am J Med. 2020;133(5):605–612.e1. doi: 10.1016/j.amjmed.2019.10.020.
- Rodrigues M.S., do Nascimento N.B., Farias H.R., et al. Microglia contribute to cognitive decline in hypercholesterolemic LDLr-/-mice. J Neurochem. 2024;168(8):1565–1586. doi: 10.1111/jnc.15952.
- Yao H., Farnier M., Tribouillard L., et al. Coronary lesion complexity in patients with heterozygous familial hypercholesterolemia hospitalized for acute myocardial infarction: data from the RICO survey. Lipids Health Dis. 2021;20(1):45. doi: 10.1186/s12944-021-01467-z.
- McGowan M.P., Hosseini Dehkordi S.H., et al. Diagnosis and treatment of heterozygous familial hypercholesterolemia. J Am Heart Assoc. 2019;8(24):e013225. doi: 10.1161/JAHA.119.013225.
- Ложкина Н.Г., Спиридонов А.Н. Клинический случай инфаркта миокарда с неуточненной формой семейной гиперхолестеринемии. Атеросклероз. 2021;17(4):74–78. [Lozhkina N.G., Spiridonov A.N. Clinical case of myocardial infarction with unspecified familial hypercholesterolemia. Ateroscleroz. 2021;17(4):74–78. (In Russ.)]. doi: 10.52727/2078-256X-2021-17-4-74-78.
补充文件
